A finely regulated system of airway epithelial development governs the differentiation of
motile ciliated cells of the human respiratory tract, conferring the body's mucociliary …

In vertebrates, multiciliated cells (MCCs) are terminally differentiated cells that line the
airway tracts, brain ventricles, and reproductive ducts. Each MCC contains dozens to …

Axonemal protein complexes, such as outer (ODA) and inner (IDA) dynein arms, are
responsible for the generation and regulation of flagellar and ciliary beating. Studies in …

Primary ciliary dyskinesia (PCD) is a genetic disorder of motile cilia. Clinical features include
chronic oto-sino-pulmonary disease, laterality defects, and male fertility reflecting impaired …

The adult spinal cord stem cell potential resides within the ependymal cell population and
declines with age. Ependymal cells are, however, heterogeneous, and the biological …

Background Male infertility is a worldwide population health concern, but its aetiology
remains largely understood. Although CFAP70 variants have already been reported in two …

Cis-regulatory elements have an important role in human adaptation to the living
environment. However, the lag in population genomic cohort studies and epigenomic …

Cystic fibrosis (CF) and Primary ciliary dyskinesia (PCD) are both rare chronic diseases,
inherited disorders associated with multiple complications, namely respiratory …

Motile ciliopathies are characterized by specific defects in cilia beating that result in chronic
airway disease, subfertility, ectopic pregnancy, and hydrocephalus. While many patients …

Hsp90 is a ubiquitous molecular chaperone involved in many cell signaling pathways, and
its interactions with specific chaperones and cochaperones determines which client proteins …