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Sexual dimorphism in colon cancer
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
Mouse models of colorectal cancer: Past, present and future perspectives
F Bürtin, CS Mullins… - World journal of …, 2020 - pmc.ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common diagnosed malignancy among both
sexes in the United States as well as in the European Union. While the incidence and …
sexes in the United States as well as in the European Union. While the incidence and …
Recurrent R-spondin fusions in colon cancer
Identifying and understanding changes in cancer genomes is essential for the development
of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary …
of targeted therapeutics. Here we analyse systematically more than 70 pairs of primary …
Secreted and transmembrane wnt inhibitors and activators
CM Cruciat, C Niehrs - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Signaling by the Wnt family of secreted glycoproteins plays important roles in embryonic
development and adult homeostasis. Wnt signaling is modulated by a number of …
development and adult homeostasis. Wnt signaling is modulated by a number of …
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor
gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large …
gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large …
Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
The application of primary organoid cultures containing epithelial and mesenchymal
elements to cancer modeling holds promise for combining the accurate multilineage …
elements to cancer modeling holds promise for combining the accurate multilineage …
A hyperactive piggyBac transposase for mammalian applications
DNA transposons have been widely used for transgenesis and insertional mutagenesis in
various organisms. Among the transposons active in mammalian cells, the moth-derived …
various organisms. Among the transposons active in mammalian cells, the moth-derived …
[HTML][HTML] In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma
We recently proposed that competitive endogenous RNAs (ceRNAs) sequester microRNAs
to regulate mRNA transcripts containing common microRNA recognition elements (MREs) …
to regulate mRNA transcripts containing common microRNA recognition elements (MREs) …
Molecular pathways in colorectal cancer
Colorectal cancer (CRC) is the second most common newly diagnosed cancer and accounts
for the second highest number of cancer related deaths in Australia, the third worldwide and …
for the second highest number of cancer related deaths in Australia, the third worldwide and …
[HTML][HTML] Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma
Summary LINE-1 (L1) retrotransposons are mobile genetic elements comprising∼ 17% of
the human genome. New L1 insertions can profoundly alter gene function and cause …
the human genome. New L1 insertions can profoundly alter gene function and cause …