Role of neuroinflammation in neurodegeneration development

W Zhang, D **ao, Q Mao, H **a - Signal transduction and targeted …, 2023 - nature.com
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …

[HTML][HTML] Mitochondrial dysfunction: pathophysiology and mitochondria-targeted drug delivery approaches

T Khan, R Waseem, Z Zehra, A Aiman, P Bhardwaj… - Pharmaceutics, 2022 - mdpi.com
Mitochondria are implicated in a wide range of functions apart from ATP generation, and,
therefore, constitute one of the most important organelles of cell. Since healthy mitochondria …

Mitochondria‐targeted nanoparticles in treatment of neurodegenerative diseases

Y Zhang, H Yang, D Wei, X Zhang, J Wang, X Wu… - …, 2021 - Wiley Online Library
Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

[HTML][HTML] The impact of mitochondrial dysfunction in amyotrophic lateral sclerosis

J Zhao, X Wang, Z Huo, Y Chen, J Liu, Z Zhao, F Meng… - Cells, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal
neurodegenerative disease. Although the pathogenesis of ALS remains unclear, increasing …

[HTML][HTML] The link between oxidative stress, redox status, bioenergetics and mitochondria in the pathophysiology of ALS

E Obrador, R Salvador-Palmer… - International Journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disease of the
motor system. It is characterized by the degeneration of both upper and lower motor …

The role of sonic hedgehog pathway in the development of the central nervous system and aging-related neurodegenerative diseases

C Yang, Y Qi, Z Sun - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The Sonic hedgehog (SHH) pathway affects neurogenesis and neural patterning during the
development of the central nervous system. Dysregulation of the SHH pathway in the brain …

Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases

CP Chang, KC Wu, CY Lin, Y Chern - Journal of Biomedical Science, 2021 - Springer
In modern societies, with an increase in the older population, age-related
neurodegenerative diseases have progressively become greater socioeconomic burdens …

[HTML][HTML] Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of …

Y Zhou, J Tang, J Lan, Y Zhang, H Wang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting
both upper and lower motor neurons (MNs) with large unmet medical needs. Multiple …

The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders

A Prajapati, S Mehan, Z Khan - Biogerontology, 2023 - Springer
Sonic hedgehog (Shh) signaling is an essential central nervous system (CNS) pathway
involved during embryonic development and later life stages. Further, it regulates cell …

New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis

F Theunissen, PK West, S Brennan, B Petrović… - Translational …, 2021 - Springer
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by selective, early degeneration of motor neurons in the brain and spinal cord …