▪ Abstract Cys2His2 zinc finger proteins offer a stable and versatile framework for the design
of proteins that recognize desired target sites on double-stranded DNA. Individual fingers …

RNA‐binding proteins play essential roles in the regulation of gene expression. Many have
modular structures and combine relatively few common domains in various arrangements to …

Puf proteins bind RNA sequence specifically and regulate translation and stability of target
mRNAs. A “code” for RNA recognition has been deduced from crystal structures of the Puf …

ABSTRACT Coronavirus (CoV) nonstructural protein 14 (nsp14) is a 60-kDa protein
encoded by the replicase gene that is part of the replication-transcription complex. It is a …

The zinc finger domain is a very ubiquitous structural element whose hallmark is the
coordination of a zinc atom by several amino acid residues (cysteines and histidines, and …

Recently, progress has been made towards the structural characterization of the novel folds
of RNA-bound arginine-rich peptides and the architecture of their peptide-binding RNA …

MRE-binding transcription factor-1 (MTF-1) contains six Cys2-His2 zinc finger sequences,
and it has been suggested that the zinc finger domain itself may function as a zinc sensor in …

Recessive mutations that suppress the late‐flowering phenotype conferred by FRIGIDA
(FRI) and FLOWERING LOCUS C (FLC) and which also result in serrated leaf morphology …

Within the last 20 years, the understanding of the biology of the 'classical'or Cys2His2 zinc
finger domain has progressed rapidly from the initial identification of the zinc finger as a …

The rapidly expanding database of RNA structures and protein complexes is beginning to
lead to the successful design of specific RNA-binding molecules. Recent combinatorial and …