Cyclin-dependent kinases in breast cancer: expression pattern and therapeutic implications
Presently, breast cancer (BC) is one of the most common malignancies diagnosed and the
leading cause of tumor-related deaths among women worldwide. Cell cycle dysregulation is …
leading cause of tumor-related deaths among women worldwide. Cell cycle dysregulation is …
Targeting CDK2 in cancer: challenges and opportunities for therapy
Highlights•CDK2 has key roles in cell cycle, DNA replication and DNA damage.•Multiple
biomarkers can indicate increased CDK2 activity.•Some cancers have particular …
biomarkers can indicate increased CDK2 activity.•Some cancers have particular …
Inhibitors of cyclin-dependent kinases as cancer therapeutics
SR Whittaker, A Mallinger, P Workman… - Pharmacology & …, 2017 - Elsevier
Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …
CDK7 inhibitors as anticancer drugs
GP Sava, H Fan, RC Coombes, L Buluwela… - Cancer and Metastasis …, 2020 - Springer
Abstract Cyclin-dependent kinase 7 (CDK7), along with cyclin H and MAT1, forms the CDK-
activating complex (CAK), which directs progression through the cell cycle via T-loop …
activating complex (CAK), which directs progression through the cell cycle via T-loop …
Targeting CDK9 reactivates epigenetically silenced genes in cancer
H Zhang, S Pandey, M Travers, H Sun, G Morton… - Cell, 2018 - cell.com
Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …
CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38α/MYC/PD-L1 signaling in non-small cell lung cancer
J Wang, R Zhang, Z Lin, S Zhang, Y Chen… - Journal of Hematology & …, 2020 - Springer
Background The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA
polymerase-II-based transcription and promotes tumor progression. However, the …
polymerase-II-based transcription and promotes tumor progression. However, the …
ICEC0942, an orally bioavailable selective inhibitor of CDK7 for cancer treatment
Recent reports indicate that some cancer types are especially sensitive to transcription
inhibition, suggesting that targeting the transcriptional machinery provides new approaches …
inhibition, suggesting that targeting the transcriptional machinery provides new approaches …
The essential and multifunctional TFIIH complex
JK Rimel, DJ Taatjes - Protein Science, 2018 - Wiley Online Library
TFIIH is a 10‐subunit complex that regulates RNA polymerase II (pol II) transcription but also
serves other important biological roles. Although much remains unknown about TFIIH …
serves other important biological roles. Although much remains unknown about TFIIH …
[HTML][HTML] An insight into the emerging role of cyclin-dependent kinase inhibitors as potential therapeutic agents for the treatment of advanced cancers
Cancer denotes a pathological manifestation that is characterized by hyperproliferation of
cells. It has anticipated that a better understanding of disease pathogenesis and the role of …
cells. It has anticipated that a better understanding of disease pathogenesis and the role of …
Therapeutic targeting of transcriptional cyclin-dependent kinases
The fact that many cancer types display transcriptional addiction driven by dysregulation of
oncogenic enhancers and transcription factors has led to increased interest in a group of …
oncogenic enhancers and transcription factors has led to increased interest in a group of …