Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity

P Liu, C Yue, B Meng, T **ao, S Yang… - National Science …, 2024 - academic.oup.com
Selective pressures have given rise to a number of SARS-CoV-2 variants during the
prolonged course of the COVID-19 pandemic. Recently evolved variants differ from …

The accomplices: Heparan sulfates and N-glycans foster SARS-CoV-2 spike: ACE2 receptor binding and virus priming

G Paiardi, M Ferraz, M Rusnati, RC Wade - Proceedings of the National …, 2024 - pnas.org
Although it is well established that the SARS-CoV-2 spike glycoprotein binds to the host cell
ACE2 receptor to initiate infection, far less is known about the tissue tropism and host cell …

[PDF][PDF] Nanomechanical footprint of SARS-CoV-2 variants in complex with a potent nanobody by molecular simulations

AB Poma, LF Cofas - researchgate.net
Rational design of novel antibody therapeutics against viral infections such as coronavirus
relies on surface complementarity and high affinity for their effectiveness. Here, we explore …