Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …

Polyubiquitination of proteins has a pivotal role in the regulation of numerous cellular
functions such as protein degradation, DNA repair and cell signaling. As deregulation of …

Protein ubiquitination is a reversible reaction, in which the ubiquitin chains are
deconjugated by a family of deubiquitinases (DUBs). The presence of a large number of …

NF-κB (nuclear factor-κB) transcription factors have multiple critical roles in the regulation of
immune responses. In unstimulated cells, NF-κB proteins are sequestered in the cytoplasm …

Antigen receptors on the surface of B lymphocytes trigger adaptive immune responses after
encountering their cognate antigens but also control a series of antigen-independent …

The nuclear factor‐κB (NF‐κB) pathway is a critical regulator of innate and adaptive
immunity. Noncanonical K63‐linked polyubiquitination plays a key regulatory role in NF‐κB …

Ubiquitylation is a fundamental mechanism of signal transduction that regulates immune
responses and many other biological processes. Similar to phosphorylation, ubiquitylation is …

Nuclear factor-kappa B (NF-κB) is a critical regulator of multiple biological functions
including innate and adaptive immunity and cell survival. Activation of NF-κB is tightly …

The paracaspase mucosa‐associated lymphoid tissue 1 (MALT1) is central to lymphocyte
activation and lymphomagenesis. MALT1 mediates antigen receptor signalling to NF‐κB by …