Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures
that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and …

High-resolution episcopic microscopy (HREM) is an imaging technique that permits the
simple and rapid generation of three-dimensional (3D) digital volume data of histologically …

Background Genetic variants in COL4A1 and COL4A2 (encoding collagen IV alpha chain
1/2) occur in genetic and sporadic forms of cerebral small vessel disease (CSVD), a leading …

For decades, clearing and staining with Alcian Blue and Alizarin Red has been the gold
standard to image vertebrate skeletal development. Here, we present an alternate approach …

Gene editing and subsequent cloning techniques offer great potential not only in genetic
disease correction in domestic animals but also in livestock production by enhancement of …

Careful phenotype analysis of genetically altered mouse embryos/fetuses is vital for
deciphering the function of pre-and perinatally lethal genes. Usually this involves comparing …

Approximately one‐third of randomly produced knockout mouse lines produce homozygous
offspring, which fail to survive the perinatal period. The majority of these die around or after …

An essential step in researching human central nervous system (CNS) disorders is the
search for appropriate mouse models that can be used to investigate both genetic and …

While traditionally the function of the extracellular matrix and the basement membrane was
considered to be providing structural support, it is now clear that this only covers one aspect …

Episcopic imaging using techniques such as High Resolution Episcopic Microscopy (HREM)
and its variants, allows biological samples to be visualized in three dimensions over a large …