The essential role of the cellular prion protein (PrP C) in prion disorders such as Creutzfeldt–
Jakob disease is well documented. Moreover, evidence is accumulating that PrP C may act …

Introduction Human prion diseases are heterogeneous, and often rapidly progressive,
transmissible neurodegenerative disorders associated with misfolded prion protein (PrP) …

The understanding of the pathogenesis and mechanisms of diseases requires a
multidisciplinary approach, involving clinical observation, correlation to pathological …

PrPC, the cellular isoform of the prion protein, serves to transduce the neurotoxic effects of
PrPSc, the infectious isoform, but how this occurs is mysterious. Here, using a combination …

The initial report that cellular prion protein (PrP C) mediates toxicity of amyloid-β species
linked to Alzheimer's disease was initially treated with scepticism, but growing evidence …

Three decades after the discovery of prions as the cause of Creutzfeldt-Jakob disease and
other transmissible spongiform encephalopathies, we are still nowhere close to finding an …

Prion diseases are devastating neurodegenerative diseases caused by the structural
conversion of the normally benign prion protein (PrPC) to an infectious, disease-associated …

Conventional vaccinations and immunotherapies have encountered major roadblocks in
preventing infectious diseases like HIV, influenza, and malaria. These challenges are due to …

Alzheimer's disease (AD) is characterized by episodic memory impairment that often
precedes clinical diagnosis by many years. Probing the mechanisms of such impairment …

Progress in therapeutics for rare disorders like prion disease is impeded by the lack of
validated outcome measures and a paucity of natural history data derived from prospective …