Obesity has become a major public health problem. Given the current increase in life
expectancy, the prevalence of obesity also raises steadily among older age groups. The …

Adipose tissue has long been identified as the major site of vitamin D storage. Recent
studies have demonstrated that VDR and vitamin D metabolizing enzymes are expressed in …

Insulin binds the insulin receptor (IR) and regulates anabolic processes in target tissues.
Impaired IR signalling is associated with multiple diseases, including diabetes, cancer and …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Lipid rafts are subdomains of the plasma membrane that contain high concentrations of
cholesterol and glycosphingolipids. They exist as distinct liquid-ordered regions of the …

Caveolae are small, bulb-shaped plasma membrane invaginations. Mutations that ablate
caveolae lead to diverse phenotypes in mice and humans, making it challenging to uncover …

Although they were discovered more than 50 years ago, caveolae have remained enigmatic
plasmalemmal organelles. With their characteristic “flasklike” shape and virtually ubiquitous …

Among the membrane compartments of a cell, vesicles known as “caveolae” have long
defied functional characterization. However, since the identification of a family of proteins …

Gaps remain in our understanding of the precise molecular mechanisms by which insulin
regulates glucose uptake in fat and muscle cells. Recent evidence suggests that insulin …

Statins are the gold-standard treatment for the prevention of primary and secondary
cardiovascular disease, which is the leading cause of mortality worldwide. Despite the safety …