The cholinergic system in the pathophysiology and treatment of Alzheimer's disease

H Hampel, MM Mesulam, AC Cuello, MR Farlow… - Brain, 2018 - academic.oup.com
Cholinergic synapses are ubiquitous in the human central nervous system. Their high
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …

Review of pharmacotherapeutic targets in Alzheimer's disease and its management using traditional medicinal plants

PN Tripathi, A Lodhi, SN Rai, NK Nandi… - Degenerative …, 2024 - Taylor & Francis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline, memory loss, and impaired daily functioning. While there is currently no …

Gut microbiome alterations in Alzheimer's disease

NM Vogt, RL Kerby, KA Dill-McFarland, SJ Harding… - Scientific reports, 2017 - nature.com
Alzheimer's disease (AD) is the most common form of dementia. However, the
etiopathogenesis of this devastating disease is not fully understood. Recent studies in …

Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier

DB Vieira, LF Gamarra - International journal of nanomedicine, 2016 - Taylor & Francis
This review summarizes articles that have been reported in literature on liposome-based
strategies for effective drug delivery across the blood–brain barrier. Due to their unique …

Effects of virtual reality intervention on cognition and motor function in older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis

S Zhu, Y Sui, Y Shen, Y Zhu, N Ali, C Guo… - Frontiers in aging …, 2021 - frontiersin.org
Background: Virtual reality (VR) intervention is an innovative and efficient rehabilitative tool
for patients affected by stroke, Parkinson's disease, and other neurological disorders. This …

[HTML][HTML] Acetylcholine bidirectionally regulates learning and memory

Q Huang, C Liao, F Ge, J Ao, T Liu - Journal of Neurorestoratology, 2022 - Elsevier
Acetylcholine (ACh) is one of the most important neurotransmitters in the central cholinergic
system; it specifically binds to muscarinic and nicotinic receptors and is degraded by …

Current and future treatments for Alzheimer's disease

KG Yiannopoulou… - Therapeutic advances in …, 2013 - journals.sagepub.com
Alzheimer's dementia (AD) is increasingly being recognized as one of the most important
medical and social problems in older people in industrialized and non-industrialized …

Neurodegenerative diseases: Regenerative mechanisms and novel therapeutic approaches

R Hussain, H Zubair, S Pursell, M Shahab - Brain sciences, 2018 - mdpi.com
Regeneration refers to regrowth of tissue in the central nervous system. It includes
generation of new neurons, glia, myelin, and synapses, as well as the regaining of essential …

Bioinorganic chemistry of Alzheimer's disease

KP Kepp - Chemical reviews, 2012 - ACS Publications
Alzheimer's disease (AD) 1− 3 is the most common form of dementia (estimated∼ 50− 60%
of all cases), associated with loss of memory (in particular episodic memory), cognitive …

New approaches for the treatment of Alzheimer's disease

PV Fish, D Steadman, ED Bayle, P Whiting - Bioorganic & medicinal …, 2019 - Elsevier
Alzheimer's disease (AD) is the most prevalent chronic neurodegenerative disease. Current
approved therapies are symptomatic treatments having some effect on cognitive function …