Principles of nanoparticle formation by flash nanoprecipitation

WS Saad, RK Prud'homme - Nano Today, 2016 - Elsevier
Rapid precipitation is an efficient approach for engineering materials at the nanoscale. By
controlling solute nucleation and growth rates in solvent precipitation processes, the size of …

[HTML][HTML] Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles

J Tao, SF Chow, Y Zheng - Acta pharmaceutica sinica B, 2019 - Elsevier
Nanoparticles are considered to be a powerful approach for the delivery of poorly water-
soluble drugs. One of the main challenges is develo** an appropriate method for …

[HTML][HTML] In vitro release study of the polymeric drug nanoparticles: development and validation of a novel method

J Weng, HHY Tong, SF Chow - Pharmaceutics, 2020 - mdpi.com
The in vitro release study is a critical test to assess the safety, efficacy, and quality of
nanoparticle-based drug delivery systems, but there is no compendial or regulatory …

Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin

Z He, JL Santos, H Tian, H Huang, Y Hu, L Liu… - Biomaterials, 2017 - Elsevier
Controlled delivery of protein would find diverse therapeutic applications. Formulation of
protein nanoparticles by polyelectrolyte complexation between the protein and a natural …

Enhanced topical penetration, system exposure and anti-psoriasis activity of two particle-sized, curcumin-loaded PLGA nanoparticles in hydrogel

L Sun, Z Liu, L Wang, D Cun, HHY Tong, R Yan… - Journal of Controlled …, 2017 - Elsevier
Psoriasis is an immune-mediated skin disorder, which is triggered by the aberrant activation
of dendritic cells in skin. This activation is followed by the complex interaction between the …

Recent advances in microfluidics for the preparation of drug and gene delivery systems

MA Tomeh, X Zhao - Molecular Pharmaceutics, 2020 - ACS Publications
Drug delivery systems (DDSs) have great potential for improving the treatment of several
diseases, especially microbial infections and cancers. However, the formulation procedures …

Translational formulation of nanoparticle therapeutics from laboratory discovery to clinical scale

J Feng, CE Markwalter, C Tian, M Armstrong… - Journal of translational …, 2019 - Springer
Background “Nanomedicine” is the application of purposely designed nano-scale materials
for improved therapeutic and diagnostic outcomes, which cannot be otherwise achieved …

Nanosuspensions of poorly water-soluble drugs prepared by bottom-up technologies

J Du, X Li, H Zhao, Y Zhou, L Wang, S Tian… - International journal of …, 2015 - Elsevier
In recent years, nanosuspension has been considered effective in the delivery of water-
soluble drugs. One of the main challenges to effective drug delivery is designing an …

Scalable fabrication of uniform nanoparticles for the efficient co-encapsulation of curcumin and procyanidins driven by multiple interactions

F Feng, J Gao, L Chen, S **ao, G Huang - Food Hydrocolloids, 2023 - Elsevier
The co-delivery of curcumin (CUR) with other polyphenol bioactives often has synergistic
benefits. However, conventional co-encapsulation carriers formed by precipitation frequently …

Non-fouling flow reactors for nanomaterial synthesis

MO Besenhard, S Pal, G Gkogkos… - Reaction Chemistry & …, 2023 - pubs.rsc.org
The potential of flow chemistry for nanomaterial synthesis has been amply demonstrated in
the last decade. Robust and reproducible synthetic protocols, scalability, high-throughput …