Lipids are amongst the most important organic compounds in living organisms, where they
serve as building blocks for cellular membranes as well as energy storage and signaling …

Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with
potential applications in diagnosis, prognosis and therapeutic guidance in most pathological …

The human plasma lipidome captures risk for cardiometabolic diseases. To discover new
lipid-associated variants and understand the link between lipid species and cardiometabolic …

Ferroptosis is associated with lipid hydroperoxides generated by the oxidation of
polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione peroxidase 4 …

Trained innate immunity fosters a sustained favorable response of myeloid cells to a
secondary challenge, despite their short lifespan in circulation. We thus hypothesized that …

We present a whole-cell fully dynamical kinetic model (WCM) of JCVI-syn3A, a minimal cell
with a reduced genome of 493 genes that has retained few regulatory proteins or small …

Triglyceride cycling is the process of continuous degradation and re-synthesis of triglyceride
in cellular stores. We show in 3T3-L1 adipocytes that triglycerides are subject to rapid …

The nuclear envelope (NE) is a spherical double membrane with elastic properties. How NE
shape and elasticity are regulated by lipid chemistry is unknown. Here we discover lipid acyl …

Gene and protein expression data provide useful resources for understanding brain
function, but little is known about the lipid composition of the brain. Here, we perform …

Lipid droplet (LD) catabolism in hepatocytes is mediated by a combination of lipolysis and a
selective autophagic mechanism called lipophagy, but the relative contributions of these …