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[HTML][HTML] Oxidative stress–Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders
Oxidative stress is a complex biological process characterized by the excessive production
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …
The roles of neutrophil-derived myeloperoxidase (MPO) in diseases: the new progress
Myeloperoxidase (MPO) is a heme-containing peroxidase, mainly expressed in neutrophils
and, to a lesser extent, in monocytes. MPO is known to have a broad bactericidal ability via …
and, to a lesser extent, in monocytes. MPO is known to have a broad bactericidal ability via …
[HTML][HTML] Hypochlorous acid chemistry in mammalian cells—influence on infection and role in various pathologies
This review discusses the formation of hypochlorous acid HOCl and the role of reactive
chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO …
chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO …
[HTML][HTML] Oxidative stress and antioxidant treatments in cardiovascular diseases
W Wang, PM Kang - Antioxidants, 2020 - mdpi.com
Background: Open Access Editor's Choice Review Oxidative Stress and Antioxidant
Treatments in Cardiovascular Diseases by Wenjun Wang 1, 2 and Peter M. Kang 1,* 1 Beth …
Treatments in Cardiovascular Diseases by Wenjun Wang 1, 2 and Peter M. Kang 1,* 1 Beth …
[HTML][HTML] Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target
Myeloperoxidase is a heme-peroxidase which makes up approximately 5% of the total dry
cell weight of neutrophils where it is predominantly found in the primary (azurophilic) …
cell weight of neutrophils where it is predominantly found in the primary (azurophilic) …
[HTML][HTML] The Role of Antioxidants in the Therapy of Cardiovascular Diseases—A Literature Review
E Młynarska, J Hajdys, W Czarnik, P Fularski, K Leszto… - Nutrients, 2024 - mdpi.com
Antioxidants are endogenous and exogenous substances with the ability to inhibit oxidation
processes by interacting with reactive oxygen species (ROS). ROS, in turn, are small, highly …
processes by interacting with reactive oxygen species (ROS). ROS, in turn, are small, highly …
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases
Heme peroxidases are a major source of reactive oxidants at sites of inflammation in
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …
NETosis as a pathogenic factor for heart failure
S Ling, JW Xu - Oxidative Medicine and Cellular Longevity, 2021 - Wiley Online Library
Heart failure threatens the lives of patients and reduces their quality of life. Heart failure,
especially heart failure with preserved ejection fraction, is closely related to systemic and …
especially heart failure with preserved ejection fraction, is closely related to systemic and …
Myeloperoxidase as a multifaceted target for cardiovascular protection
Significance: Myeloperoxidase (MPO) is a heme peroxidase that is primarily expressed by
neutrophils. It has the capacity to generate several reactive species, essential for its inherent …
neutrophils. It has the capacity to generate several reactive species, essential for its inherent …
[HTML][HTML] Therapeutic inhibition of MPO stabilizes pre-existing high risk atherosclerotic plaque
Currently there are no established therapies to treat high-risk patients with unstable
atherosclerotic lesions that are prone to rupture and can result in thrombosis, abrupt arterial …
atherosclerotic lesions that are prone to rupture and can result in thrombosis, abrupt arterial …