There are many instances in life when the environment plays a critical role in the health
outcomes of an individual, yet none more so than those experienced in fetal and neonatal …

White adipose tissue is a mesenchymal tissue that begins develo** in the fetus.
Classically known for storing the body's fuel reserves, adipose tissue is now recognized as …

The phosphoinositide 3-kinase (PI3K) pathway crucially controls metabolism and cell
growth. Although different PI3K catalytic subunits are known to play distinct roles, the …

Research investigating the early programming of adult metabolic disease has in recent
years provided much mechanistic insight into how the early environment impacts on long …

In this study we determined body weight-specific fetal (umbilical) glucose uptake (UGU),
utilization (GUR), and production rates (GPR) and insulin action in intrauterine growth …

The global obesity epidemic remains poorly understood, partly because it has emerged
alongside persisting under‐nutrition in many populations. At an abstract level, obesity …

Nutrition during early mammalian development permanently influences health of the adult,
including increasing the risk of type 2 diabetes and coronary heart disease. However, the …

Context: Low birth weight (LBW) and unhealthy diets are risk factors of metabolic disease
including type 2 diabetes (T2D). Genetic, nongenetic, and epigenetic data propose a role of …

Objective Perinatal exposure to maternal obesity results in predisposition of offspring to
develop obesity later in life. Increased weight gain in offspring exposed to maternal obesity …

We determined the effects of maternal diet-induced obesity on offspring adipose tissue
insulin signalling and miRNA expression in the aetiology of insulin resistance in later life …