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Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Lipid nanotechnology
S Mashaghi, T Jadidi, G Koenderink… - International journal of …, 2013 - mdpi.com
Nanotechnology is a multidisciplinary field that covers a vast and diverse array of devices
and machines derived from engineering, physics, materials science, chemistry and biology …
and machines derived from engineering, physics, materials science, chemistry and biology …
[HTML][HTML] Lipids on the move: simulations of membrane pores, domains, stalks and curves
In this review we describe the state-of-the-art of computer simulations studies of lipid
membranes. We focus on collective lipid–lipid and lipid–protein interactions that trigger …
membranes. We focus on collective lipid–lipid and lipid–protein interactions that trigger …
LiPyphilic: A Python toolkit for the analysis of lipid membrane simulations
Molecular dynamics simulations are now widely used to study emergent phenomena in lipid
membranes with complex compositions. Here, we present LiPyphilic—a fast, fully tested …
membranes with complex compositions. Here, we present LiPyphilic—a fast, fully tested …
On the Validation of Molecular Dynamics Simulations of Saturated and cis-Monounsaturated Phosphatidylcholine Lipid Bilayers: A Comparison with Experiment
Molecular dynamics simulations of fully hydrated pure bilayers of four widely studied
phospholipids, 1, 2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1, 2-dimyristoyl-sn …
phospholipids, 1, 2-dilauroyl-sn-glycero-3-phosphocholine (DLPC), 1, 2-dimyristoyl-sn …
[HTML][HTML] Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes
This paper reviews the current knowledge on the various mechanisms for transbilayer, or flip-
flop, lipid motion in model and cell membranes, enzyme-assisted lipid transfer by flippases …
flop, lipid motion in model and cell membranes, enzyme-assisted lipid transfer by flippases …
Kinetics, statistics, and energetics of lipid membrane electroporation studied by molecular dynamics simulations
Membrane electroporation is the method to directly transfer bioactive substances such as
drugs and genes into living cells, as well as preceding electrofusion. Although much …
drugs and genes into living cells, as well as preceding electrofusion. Although much …
Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flip**
TG Pomorski, AK Menon - Progress in lipid research, 2016 - Elsevier
Membrane lipids diffuse rapidly in the plane of the membrane but their ability to flip
spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus …
spontaneously across a membrane bilayer is hampered by a significant energy barrier. Thus …
A synthetic enzyme built from DNA flips 107 lipids per second in biological membranes
Mimicking enzyme function and increasing performance of naturally evolved proteins is one
of the most challenging and intriguing aims of nanoscience. Here, we employ DNA …
of the most challenging and intriguing aims of nanoscience. Here, we employ DNA …
1H NMR Shows Slow Phospholipid Flip-Flop in Gel and Fluid Bilayers
We measured the transbilayer diffusion of 1, 2-dipalmitoyl-sn-glycero-3-phosphocholine
(DPPC) in large unilamellar vesicles, in both the gel (L β′) and fluid (L α) phases. The …
(DPPC) in large unilamellar vesicles, in both the gel (L β′) and fluid (L α) phases. The …