The neuromuscular junction in health and disease: molecular mechanisms governing synaptic formation and homeostasis

PM Rodríguez Cruz, J Cossins, D Beeson… - Frontiers in molecular …, 2020 - frontiersin.org
The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron
nerve terminal and its muscle fiber that are responsible for converting electrical impulses …

Neuromuscular junction formation, aging, and disorders

L Li, WC **ong, L Mei - Annual review of physiology, 2018 - annualreviews.org
Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory,
perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed …

To build a synapse: signaling pathways in neuromuscular junction assembly

H Wu, WC **ong, L Mei - Development, 2010 - journals.biologists.com
Synapses, as fundamental units of the neural circuitry, enable complex behaviors. The
neuromuscular junction (NMJ) is a synapse type that forms between motoneurons and …

Pathogenesis of myasthenia gravis: update on disease types, models, and mechanisms

WD Phillips, A Vincent - F1000Research, 2016 - pmc.ncbi.nlm.nih.gov
Myasthenia gravis is an autoimmune disease of the neuromuscular junction (NMJ) caused
by antibodies that attack components of the postsynaptic membrane, impair neuromuscular …

[HTML][HTML] Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

YC Jang, MS Lustgarten, Y Liu, FL Muller… - The FASEB …, 2010 - pmc.ncbi.nlm.nih.gov
Oxidative stress has been implicated in the etiology of age-related muscle loss (sarcopenia).
However, the underlying mechanisms by which oxidative stress contributes to sarcopenia …

Molecular mechanisms underlying maturation and maintenance of the vertebrate neuromuscular junction

L Shi, AKY Fu, NY Ip - Trends in neurosciences, 2012 - cell.com
The vertebrate neuromuscular junction (NMJ), a peripheral synapse formed between
motoneuron and skeletal muscle, is characterized by a protracted postnatal period of …

The neuromuscular junction and wide heterogeneity of congenital myasthenic syndromes

PM Rodríguez Cruz, J Palace, D Beeson - International journal of …, 2018 - mdpi.com
Congenital myasthenic syndromes (CMS) are genetic disorders characterised by impaired
neuromuscular transmission. This review provides an overview on CMS and highlights …

Genetics and cell biology of building specific synaptic connectivity

K Shen, P Scheiffele - Annual review of neuroscience, 2010 - annualreviews.org
The assembly of specific synaptic connections during development of the nervous system
represents a remarkable example of cellular recognition and differentiation. Neurons employ …

[HTML][HTML] Fundamental molecules and mechanisms for forming and maintaining neuromuscular synapses

SJ Burden, MG Huijbers, L Remedio - International journal of molecular …, 2018 - mdpi.com
The neuromuscular synapse is a relatively large synapse with hundreds of active zones in
presynaptic motor nerve terminals and more than ten million acetylcholine receptors …

Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junction

N Singhal, PT Martin - Developmental neurobiology, 2011 - Wiley Online Library
The vertebrate neuromuscular junction (NMJ) remains the best‐studied model for
understanding the mechanisms involved in synaptogenesis, due to its relatively large size …