Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators
Cardiac pump function arises from a series of highly orchestrated events across multiple
scales. Computational electromechanics can encode these events in physics-constrained …
scales. Computational electromechanics can encode these events in physics-constrained …
[HTML][HTML] Harnessing 12-lead ECG and MRI data to personalise repolarisation profiles in cardiac digital twin models for enhanced virtual drug testing
Cardiac digital twins are computational tools capturing key functional and anatomical
characteristics of patient hearts for investigating disease phenotypes and predicting …
characteristics of patient hearts for investigating disease phenotypes and predicting …
Enhanced optimization-based method for the generation of patient-specific models of Purkinje networks
Cardiac Purkinje networks are a fundamental part of the conduction system and are known
to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje …
to initiate a variety of cardiac arrhythmias. However, patient-specific modeling of Purkinje …
Modelling and simulation for preclinical cardiac safety assessment of drugs with human iPSC-derived cardiomyocytes
P Kügler - Jahresbericht der Deutschen Mathematiker …, 2020 - Springer
As a potentially life threatening side effect, pharmaceutical compounds may trigger cardiac
arrhythmias by impeding the heart's electrical and mechanical function. For this reason, any …
arrhythmias by impeding the heart's electrical and mechanical function. For this reason, any …
In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and Purkinje in human
Human-based modelling and simulation offer an ideal testbed for novel medical therapies to
guide experimental and clinical studies. Myocardial infarction (MI) is a common cause of …
guide experimental and clinical studies. Myocardial infarction (MI) is a common cause of …
Considering population variability of electrophysiological models improves the in silico assessment of drug-induced torsadogenic risk
Abstract Background and Objective In silico tools are known to aid in drug cardiotoxicity
assessment. However, computational models do not usually consider electrophysiological …
assessment. However, computational models do not usually consider electrophysiological …
Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies
Computer models of the human ventricular cardiomyocyte action potential (AP) have
reached a level of detail and maturity that has led to an increasing number of applications in …
reached a level of detail and maturity that has led to an increasing number of applications in …
A parameter representing missing charge should be considered when calibrating action potential models
Computational models of the electrical potential across a cell membrane are longstanding
and vital tools in electrophysiology research and applications. These models describe how …
and vital tools in electrophysiology research and applications. These models describe how …
[HTML][HTML] Alleviating the Effects of Short QT Syndrome Type 3 by Allele-Specific Suppression of the KCNJ2 Mutant Allele
R Wilders - International Journal of Molecular Sciences, 2024 - mdpi.com
Short QT syndrome type 3 (SQTS3 or SQT3), which is associated with life-threatening
cardiac arrhythmias, is caused by heterozygous gain-of-function mutations in the KCNJ2 …
cardiac arrhythmias, is caused by heterozygous gain-of-function mutations in the KCNJ2 …
Cardiac Digital Twin Pipeline for Virtual Therapy Evaluation
Cardiac digital twins are computational tools capturing key functional and anatomical
characteristics of patient hearts for investigating disease phenotypes and predicting …
characteristics of patient hearts for investigating disease phenotypes and predicting …