Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …

MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are responsible for RNA
silencing and post-transcriptional regulation of gene expression. They can mediate a fine …

Cancer is the second leading cause of death globally, trailing only heart disease. In the
United States alone, 1.9 million new cancer cases and 609,360 deaths were recorded for …

In this study, we integrate the outcomes of co-expression network analysis with the human
interactome network to predict novel putative disease genes and modules. We first apply the …

Network medicine is a rapidly evolving new field of medical research, which combines
principles and approaches of systems biology and network science, holding the promise to …

In pulmonary arterial hypertension (PAH), the Warburg effect (glycolytic shift) and
mitochondrial fission are determinants of phenotype alterations characteristic of the disease …

Physical activity may offset cognitive decline and dementia, but the molecular mechanisms
by which it promotes neuroprotection remain elusive. In the absence of disease-modifying …

Identification of disease-associated miRNAs (disease miRNAs) are critical for understanding
etiology and pathogenesis. Most previous methods focus on integrating similarities and …

The freshwater snail, Biomphalaria glabrata, is an important intermediate host in the life
cycle for the human parasite Schistosoma mansoni, the causative agent of schistosomiasis …

The SARS-CoV-2 pandemic is a worldwide public health emergency. Despite the beginning
of a vaccination campaign, the search for new drugs to appropriately treat COVID-19 …