Translational investigation of the therapeutic potential of cannabidiol (CBD): toward a new age

JA Crippa, FS Guimarães, AC Campos… - Frontiers in …, 2018 - frontiersin.org
Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a
compound that does not produce the typical subjective effects of marijuana. Objectives: The …

[HTML][HTML] Cannabinoids in the treatment of epilepsy: hard evidence at last?

E Perucca - Journal of epilepsy research, 2017 - ncbi.nlm.nih.gov
The interest in cannabis-based products for the treatment of refractory epilepsy has
skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ …

Pharmacological and therapeutic properties of cannabidiol for epilepsy

V Franco, E Perucca - Drugs, 2019 - Springer
Cannabidiol (CBD) is a major active component of the Cannabis plant, which, unlike
tetrahydrocannabinol (THC), is devoid of euphoria-inducing properties. During the last 10 …

Neuropharmacological effects of the main phytocannabinoids: a narrative review

RG Dos Santos, JEC Hallak, JAS Crippa - … and neuropsychiatric disorders, 2021 - Springer
Cannabis can synthetize more than 400 compounds, including terpenes, flavonoids, and
more than 100 phytocannabinoids. The main phytocannabinoids are Δ-9 …

Role of cannabidiol in the therapeutic intervention for substance use disorders

F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2021 - frontiersin.org
Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …

The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights

W Lazarini-Lopes, RA Do Val-da Silva… - Neuroscience & …, 2020 - Elsevier
Epilepsy is a neurological disorder characterized by the presence of seizures and
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …

Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels

LR Vilela, IV Lima, ÉB Kunsch, HPP Pinto… - Epilepsy & Behavior, 2017 - Elsevier
Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits
experimental seizures in animal models and alleviates certain types of intractable epilepsies …

Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms

GP Silote, A Sartim, A Sales, A Eskelund… - Journal of chemical …, 2019 - Elsevier
Significant limitations with the currently available antidepressant treatment strategies have
inspired research on finding new and more efficient drugs to treat depression. Cannabidiol …

Cannabidiol: a review of clinical efficacy and safety in epilepsy

D Samanta - Pediatric neurology, 2019 - Elsevier
Several new antiepileptic medicines became available for clinical use in the last two
decades. However, the prognosis of epilepsy remains unchanged, with approximately one …

Emerging potential of cannabidiol in reversing proteinopathies

R Dash, MC Ali, I Jahan, YA Munni, S Mitra… - Ageing research …, 2021 - Elsevier
The aberrant accumulation of disease-specific protein aggregates accompanying cognitive
decline is a pathological hallmark of age-associated neurological disorders, also termed as …