Translational investigation of the therapeutic potential of cannabidiol (CBD): toward a new age
Background: Among the many cannabinoids in the cannabis plant, cannabidiol (CBD) is a
compound that does not produce the typical subjective effects of marijuana. Objectives: The …
compound that does not produce the typical subjective effects of marijuana. Objectives: The …
[HTML][HTML] Cannabinoids in the treatment of epilepsy: hard evidence at last?
E Perucca - Journal of epilepsy research, 2017 - ncbi.nlm.nih.gov
The interest in cannabis-based products for the treatment of refractory epilepsy has
skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ …
skyrocketed in recent years. Marijuana and other cannabis products with high content in Δ …
Pharmacological and therapeutic properties of cannabidiol for epilepsy
V Franco, E Perucca - Drugs, 2019 - Springer
Cannabidiol (CBD) is a major active component of the Cannabis plant, which, unlike
tetrahydrocannabinol (THC), is devoid of euphoria-inducing properties. During the last 10 …
tetrahydrocannabinol (THC), is devoid of euphoria-inducing properties. During the last 10 …
Neuropharmacological effects of the main phytocannabinoids: a narrative review
Cannabis can synthetize more than 400 compounds, including terpenes, flavonoids, and
more than 100 phytocannabinoids. The main phytocannabinoids are Δ-9 …
more than 100 phytocannabinoids. The main phytocannabinoids are Δ-9 …
Role of cannabidiol in the therapeutic intervention for substance use disorders
F Navarrete, MS García-Gutiérrez… - Frontiers in …, 2021 - frontiersin.org
Drug treatments available for the management of substance use disorders (SUD) present
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …
multiple limitations in efficacy, lack of approved treatments or alarming relapse rates. These …
The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights
W Lazarini-Lopes, RA Do Val-da Silva… - Neuroscience & …, 2020 - Elsevier
Epilepsy is a neurological disorder characterized by the presence of seizures and
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …
Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels
LR Vilela, IV Lima, ÉB Kunsch, HPP Pinto… - Epilepsy & Behavior, 2017 - Elsevier
Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits
experimental seizures in animal models and alleviates certain types of intractable epilepsies …
experimental seizures in animal models and alleviates certain types of intractable epilepsies …
Emerging evidence for the antidepressant effect of cannabidiol and the underlying molecular mechanisms
GP Silote, A Sartim, A Sales, A Eskelund… - Journal of chemical …, 2019 - Elsevier
Significant limitations with the currently available antidepressant treatment strategies have
inspired research on finding new and more efficient drugs to treat depression. Cannabidiol …
inspired research on finding new and more efficient drugs to treat depression. Cannabidiol …
Cannabidiol: a review of clinical efficacy and safety in epilepsy
D Samanta - Pediatric neurology, 2019 - Elsevier
Several new antiepileptic medicines became available for clinical use in the last two
decades. However, the prognosis of epilepsy remains unchanged, with approximately one …
decades. However, the prognosis of epilepsy remains unchanged, with approximately one …
Emerging potential of cannabidiol in reversing proteinopathies
The aberrant accumulation of disease-specific protein aggregates accompanying cognitive
decline is a pathological hallmark of age-associated neurological disorders, also termed as …
decline is a pathological hallmark of age-associated neurological disorders, also termed as …