For over two decades, the prime objective of the chemical biology community studying G-
quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to …

Break-induced replication (BIR) repairs one-ended double-strand DNA breaks through
invasion into a homologous template followed by DNA synthesis. Different from S-phase …

PIF1 is a conserved helicase and G4 DNA binding and unwinding enzyme, with roles in
genome stability. Human PIF1 (hPIF1) is poorly understood, but its functions can become …

Efficient and faithful replication of the genome is essential to maintain genome stability.
Replication is carried out by a multiprotein complex called the replisome, which encounters …

The convergence of two DNA replication forks creates unique problems during DNA
replication termination. In E. coli and SV40, the release of torsional strain by type II …

Saccharomyces cerevisiae Pif1 is a multi-functional DNA helicase that plays diverse roles in
the maintenance of the nuclear and mitochondrial genomes. Two isoforms of Pif1 are …

The two PIF1 family helicases in Saccharomyces cerevisiae, Rrm3, and ScPif1, associate
with thousands of sites throughout the genome where they perform overlap** and distinct …

Pif1 family helicases are multifunctional proteins conserved in eukaryotes, from yeast to
humans. They are important for the genome maintenance in both nuclei and mitochondria …

Members of the conserved Pif1 family of 5′-3′ DNA helicases can unwind G4s and
mitigate their negative impact on genome stability. In Saccharomyces cerevisiae, two Pif1 …

The human ribosomal DNA (rDNA) locus encodes a variety of long non-coding RNAs
(lncRNAs). Among them, the canonical ribosomal RNAs that are the catalytic components of …