Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
Assessment of disease-related cognitive impairments using the novel object recognition (NOR) task in rodents
B Grayson, M Leger, C Piercy, L Adamson… - Behavioural brain …, 2015 - Elsevier
The novel object recognition test (NOR) test is a two trial cognitive paradigm that assesses
recognition memory. Recognition memory is disturbed in a range of human disorders and …
recognition memory. Recognition memory is disturbed in a range of human disorders and …
Defeat stress in rodents: from behavior to molecules
C Hammels, E Pishva, J De Vry… - Neuroscience & …, 2015 - Elsevier
Mood and anxiety disorders are prevalent conditions affecting one out of four people during
lifetime. The development of high validity animal models to study these disorders has been a …
lifetime. The development of high validity animal models to study these disorders has been a …
The importance of the NRG-1/ErbB4 pathway for synaptic plasticity and behaviors associated with psychiatric disorders
A Shamir, OB Kwon, I Karavanova… - Journal of …, 2012 - Soc Neuroscience
Neuregulin 1 (NRG-1) and its receptor ErbB4 have emerged as biologically plausible
schizophrenia risk factors, modulators of GABAergic and dopaminergic neurotransmission …
schizophrenia risk factors, modulators of GABAergic and dopaminergic neurotransmission …
Neuregulin-1 and schizophrenia in the genome-wide association study era
Clinical and pre-clinical evidence has implicated neuregulin 1 (NRG1) as a critical
component in the pathophysiology of schizophrenia. However, the arrival of the genome …
component in the pathophysiology of schizophrenia. However, the arrival of the genome …
Schizophrenia and depression co-morbidity: what we have learned from animal models
JN Samsom, AHC Wong - Frontiers in psychiatry, 2015 - frontiersin.org
Patients with schizophrenia are at an increased risk for the development of depression.
Overlap in the symptoms and genetic risk factors between the two disorders suggests a …
Overlap in the symptoms and genetic risk factors between the two disorders suggests a …
Neuronal migration abnormalities and its possible implications for schizophrenia
K Muraki, K Tanigaki - Frontiers in neuroscience, 2015 - frontiersin.org
Schizophrenia is a complex mental disorder that displays behavioral deficits such as
decreased sensory gating, reduced social interaction and working memory deficits. The …
decreased sensory gating, reduced social interaction and working memory deficits. The …
Animal models of gene–environment interaction in schizophrenia: A dimensional perspective
Y Ayhan, R McFarland, MV Pletnikov - Progress in neurobiology, 2016 - Elsevier
Schizophrenia has long been considered as a disorder with multifactorial origins. Recent
discoveries have advanced our understanding of the genetic architecture of the disease …
discoveries have advanced our understanding of the genetic architecture of the disease …
[HTML][HTML] Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test
Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been
reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We …
reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We …
Losing your inhibition: linking cortical GABAergic interneurons to schizophrenia
GABAergic interneurons of the cerebral cortex (cINs) play crucial roles in many aspects of
cortical function. The diverse types of cINs are classified into subgroups according to their …
cortical function. The diverse types of cINs are classified into subgroups according to their …