Cardiovascular disease, with atherosclerosis as the major underlying factor, remains the
leading cause of death worldwide. It is well established that cholesterol ester-enriched foam …

Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …

Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER)
is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport …

The low-density lipoprotein (LDL) is a major cholesterol carrier in circulation and is
internalized into cells through LDL receptor (LDLR)-mediated endocytosis. The LDLR …

Abnormal distribution of cellular cholesterol is associated with numerous diseases, including
cardiovascular and neurodegenerative diseases. Regulated transport of cholesterol is …

Incomplete understanding of how hepatosteatosis transitions to fibrotic non-alcoholic
steatohepatitis (NASH) has limited therapeutic options. Two molecules that are elevated in …

Contacts between organelles create microdomains that play major roles in regulating key
intracellular activities and signaling pathways, but whether they also regulate systemic …

Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …

Abstract Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption.
Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is …

In cell models, changes in the 'accessible'pool of plasma membrane (PM) cholesterol are
linked with the regulation of endoplasmic reticulum sterol synthesis and metabolism by the …