Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA
replication, providing a molecular platform that facilitates the myriad protein–protein and …

Preservation of genome integrity is an essential process for cell homeostasis. During the
course of life of a single cell, the genome is constantly damaged by endogenous and …

DNA repair mechanisms are critical for maintaining the integrity of genomic DNA, and their
loss is associated with cancer predisposition syndromes. Studies in Saccharomyces …

Post-translational modification by ubiquitin is best known for its role in targeting its
substrates for regulated degradation. However, non-proteolytic functions of the ubiquitin …

Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic
instability. Cells have evolved lesion bypass pathways such as postreplication repair (PRR) …

Replicative DNA damage bypass, mediated by the ubiquitylation of the sliding clamp protein
PCNA, facilitates the survival of a cell in the presence of genotoxic agents, but it can also …

Mutations can be beneficial under conditions in which genetic diversity is advantageous,
such as somatic hypermutation and antibody generation, but they can also be lethal when …

DNA replication is a highly demanding process regarding the energy and material supply
and must be precisely regulated, involving multiple cellular feedbacks. The slowing down or …

PCNA is a key component of DNA replication and repair machineries. DNA damage-
induced PCNA ubiquitylation serves as a molecular mark to orchestrate postreplication …

After exposure to DNA-damaging agents that block the progress of the replication fork,
monoubiquitination of proliferating cell nuclear antigen (PCNA) mediates the switch from …