In vivo dynamics of the latent reservoir for HIV-1: new insights and implications for cure
JD Siliciano, RF Siliciano - Annual Review of Pathology …, 2022 - annualreviews.org
Although antiretroviral therapy (ART) can reduce viremia to below the limit of detection and
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …
allow persons living with HIV-1 (PLWH) to lead relatively normal lives, viremia rebounds …
[HTML][HTML] Eliminating HIV reservoirs for a cure: the issue is in the tissue
K Busman-Sahay, CE Starke… - Current Opinion in …, 2021 - journals.lww.com
Elimination of tissue viral reservoirs is likely the key to generation of an effective HIV cure.
Exciting studies have come out recently that reveal crucial insights into topics ranging from …
Exciting studies have come out recently that reveal crucial insights into topics ranging from …
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
Human immunodeficiency virus (HIV) persistence during antiretroviral therapy (ART) is
associated with heightened plasma interleukin-10 (IL-10) levels and PD-1 expression. We …
associated with heightened plasma interleukin-10 (IL-10) levels and PD-1 expression. We …
Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy
JA White, FR Simonetti, S Beg… - Proceedings of the …, 2022 - National Acad Sciences
In persons living with HIV-1 (PLWH) who start antiretroviral therapy (ART), plasma virus
decays in a biphasic fashion to below the detection limit. The first phase reflects the short …
decays in a biphasic fashion to below the detection limit. The first phase reflects the short …
Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods
JA White, JT Kufera, N Bachmann, W Dai… - PLoS …, 2022 - journals.plos.org
Antiretroviral therapy (ART) effectively inhibits HIV-1 replication but is not curative due to the
persistence of a latent viral reservoir in resting CD4+ T cells. This reservoir is a major barrier …
persistence of a latent viral reservoir in resting CD4+ T cells. This reservoir is a major barrier …
Genome-wide CRISPR screens identify combinations of candidate latency reversing agents for targeting the latent HIV-1 reservoir
Reversing HIV-1 latency promotes killing of infected cells and is essential for cure strategies;
however, no single latency reversing agent (LRA) or LRA combination have been shown to …
however, no single latency reversing agent (LRA) or LRA combination have been shown to …
Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants
The decay kinetics of HIV-1-infected cells are critical to understand virus persistence. We
evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for 4 years of …
evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for 4 years of …
A highly multiplexed droplet digital PCR assay to measure the intact HIV-1 proviral reservoir
Quantifying the replication-competent HIV reservoir is essential for evaluating curative
strategies. Viral outgrowth assays (VOAs) underestimate the reservoir because they fail to …
strategies. Viral outgrowth assays (VOAs) underestimate the reservoir because they fail to …
Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA
FR Simonetti, JA White, C Tumiotto… - Proceedings of the …, 2020 - National Acad Sciences
A scalable approach for quantifying intact HIV-1 proviruses is critical for basic research and
clinical trials directed at HIV-1 cure. The intact proviral DNA assay (IPDA) is a novel …
clinical trials directed at HIV-1 cure. The intact proviral DNA assay (IPDA) is a novel …
Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy
Interleukin-10 (IL-10) is an immunosuppressive cytokine that signals through STAT3 to
regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV …
regulate T follicular helper (Tfh) cell differentiation and germinal center formation. In SIV …