Post-translational modifications in proteins: resources, tools and prediction methods

S Ramazi, J Zahiri - Database, 2021 - academic.oup.com
Posttranslational modifications (PTMs) refer to amino acid side chain modification in some
proteins after their biosynthesis. There are more than 400 different types of PTMs affecting …

Mass spectrometry-based protein footprinting for higher-order structure analysis: fundamentals and applications

XR Liu, MM Zhang, ML Gross - Chemical reviews, 2020 - ACS Publications
Proteins adopt different higher-order structures (HOS) to enable their unique biological
functions. Understanding the complexities of protein higher-order structures and dynamics …

Mechanisms of regulation of the chemokine-receptor network

MJ Stone, JA Hayward, C Huang, Z E. Huma… - International journal of …, 2017 - mdpi.com
The interactions of chemokines with their G protein-coupled receptors promote the migration
of leukocytes during normal immune function and as a key aspect of the inflammatory …

Small changes huge impact: the role of protein posttranslational modifications in cellular homeostasis and disease

TM Karve, AK Cheema - Journal of amino acids, 2011 - Wiley Online Library
Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and
have a ubiquitous role in diverse range of cellular functions. Identification, characterization …

[BOOK][B] Chemical reagents for protein modification

RL Lundblad - 2004 - taylorfrancis.com
Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Alarmins: feel the stress

P Rider, E Voronov, CA Dinarello, RN Apte… - The Journal of …, 2017 - journals.aai.org
Over the last decade, danger-associated molecular pattern molecules, or alarmins, have
been recognized as signaling mediators of sterile inflammatory responses after trauma and …

Chemoselective umpolung of thiols to episulfoniums for cysteine bioconjugation

P Hartmann, K Bohdan, M Hommrich, F Juliá… - Nature …, 2024 - nature.com
Cysteine conjugation is an important tool in protein research and relies on fast, mild and
chemoselective reactions. Cysteinyl thiols can either be modified with prefunctionalized …

The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo

MV Sundaram, N Pujol - Genetics, 2024 - academic.oup.com
Apical extracellular matrices (aECMs) coat the exposed surfaces of animal bodies to shape
tissues, influence social interactions, and protect against pathogens and other …

Post-translational modifications of protein biopharmaceuticals

G Walsh - Drug discovery today, 2010 - Elsevier
The majority of therapeutic proteins display one or more post-translational modifications
(PTMs). These modifications normally influence the biochemical and therapeutic properties …

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model

AB Kleist, AE Getschman, JJ Ziarek, AM Nevins… - Biochemical …, 2016 - Elsevier
Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions,
and dysregulated CKR signaling underpins numerous disease processes of the immune …