The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

Background The with no lysine [K](WNK) pathway consists of the structurally unique WNK
kinases, their downstream target kinases, oxidative stress responsive (OSR) 1 and …

The NLRP3 inflammasome mediates the production of proinflammatory cytokines and
initiates inflammatory cell death. Although NLRP3 is essential for innate immunity, aberrant …

Communication between cancer cells and their microenvironment plays an important role in
cancer development, but the precise mechanisms by which cancer-associated fibroblasts …

Endothelial cells (ECs) line the wall of blood vessels and regulate arterial contractility to tune
regional organ blood flow and systemic pressure. Chloride (Cl−) is the most abundant anion …

Angiogenesis is essential for growth of new blood vessels, remodeling existing vessels, and
repair of damaged vessels, and these require reorganization of endothelial cell–cell …

Metastasis is the major cause of mortality in patients with breast cancer. Many signaling
pathways have been linked to cancer invasiveness, but blockade of few protein components …

The distal nephron of the kidney has a central role in sodium and fluid homeostasis, and
disruption of this homeostasis due to mutations of with-no-lysine kinase 1 (WNK1), WNK4 …

Mammalian WNK kinases (WNKs) are serine/threonine kinases that contain four members,
WNK1–4. They function to maintain ion homeostasis and regulate blood pressure in …

With-no-lysine (K)-1 (WNK1) is the founding member of family of four protein kinases with
atypical placement of catalytic lysine that play important roles in regulating epithelial ion …