Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Introduction: Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful
methodology to study protein dynamics, protein folding, protein-protein interactions, and …

To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus
outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV …

SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane
fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 …

INTRODUCTION The ubiquitin-proteasome system comprises hundreds of distinct pathways
of degradation, which converge at the step of ubiquitin recognition by the proteasome. Five …

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) is an established method for
the interrogation of protein conformation and dynamics. While the data analysis challenge of …

Functional regulation of ligand-activated receptors is driven by alterations in the
conformational dynamics of the protein upon ligand binding. Differential hydrogen/deuterium …

Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) emerged as a tool for
biochemistry and structural biology around 25 years ago. It has since become a key …

Much of our understanding of protein structure and mechanistic function has been derived
from static high‐resolution structures. As structural biology has continued to evolve it has …

Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …