Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …

In recent decades, there has been an increasing effort to reduce the use of fossil fuels and
oil derivatives, to decrease environmental pollution, and to counteract global warming. The …

Microbes from the three domains of life, Bacteria, Archaea, and Eukarya, share the need to
sense and respond to changes in the external and internal concentrations of protons. When …

Microbial production of fuels and chemicals from renewable carbohydrate feedstocks offers
sustainable and economically attractive alternatives to their petroleum-based production …

Increased human population and the rapid decline of fossil fuels resulted in a global
tendency to look for alternative fuel sources. Environmental concerns about fossil fuel …

Background Predictable control of gene expression is necessary for the rational design and
optimization of cell factories. In the yeast Saccharomyces cerevisiae, the promoter is one of …

Highlights•Recent technological advances amplify the power of yeast evolutionary
engineering.•Dynamic selection regimes can mitigate phenotypic trade-off …

Sucrose is an abundant, readily available and inexpensive substrate for industrial
biotechnology processes and its use is demonstrated with much success in the production of …

This review summarizes progress in the construction of efficient yeast ethanol producers
from glucose/sucrose and lignocellulose. Saccharomyces cerevisiae is the major industrial …

Adaptive laboratory evolution (ALE) is an evolutionary engineering approach in artificial
conditions that improves organisms through the imitation of natural evolution. Due to the …