Abstract Recently, Poly (lactic-co-glycolic) Acid (PLGA) has garnered great attention as
foundational material for biomedical applications due to inherent biocompatibility, and …

Melanoma is one of the most severe cancerous diseases. The cells employ multiple
signaling pathways, such as ERK, HGF/c-MET, WNT, and COX-2 to cause the cell …

Cytokines can coordinate robust immune responses, holding great promise as therapeutics
against infections, autoimmune diseases, and cancers. In cancer treatment, numerous pro …

Tumor immunotherapy has emerged as a formidable strategy, demonstrating substantial
achievements in the field of cancer treatment. Despite its remarkable success, intrinsic …

Systemic administration of interleukin (IL)-12 induces potent anti-tumor immune responses
in preclinical cancer models through the systemic activation of effector immune cells and …

Clinical trials exploring bolus intravenous delivery of interleukin‐12 (IL‐12) for treatment of
solid tumors ultimately failed due to lack of clinical response and severe dose‐limiting …

Introduction Cytokine immunotherapy is a growing field for the treatment of cancer, infectious
disease, autoimmunity, and other ailments. Therapeutic cytokines are a class of secreted …