Extrapineal melatonin: sources, regulation, and potential functions
Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …
considered an indoleamine from a biochemical point of view because the melatonin …
Membrane melatonin receptors activated cell signaling in physiology and disease
The pineal hormone melatonin has attracted great scientific interest since its discovery in
1958. Despite the enormous number of basic and clinical studies the exact role of melatonin …
1958. Despite the enormous number of basic and clinical studies the exact role of melatonin …
Benefits and adverse events of melatonin use in the elderly
Melatonin is a hormone secreted by the pineal gland in accordance with the circadian
rhythm when the light level decreases. Reduction of melatonin secretion with age may be …
rhythm when the light level decreases. Reduction of melatonin secretion with age may be …
Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies
M Wilhelmsen, I Amirian, RJ Reiter… - Journal of pineal …, 2011 - Wiley Online Library
Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin
has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative …
has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative …
[HTML][HTML] Molecular mechanisms of melatonin-mediated cell protection and signaling in health and disease
DM Kopustinskiene, J Bernatoniene - Pharmaceutics, 2021 - mdpi.com
Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …
Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression
L Zhang, P Su, C Xu, C Chen, A Liang… - Journal of pineal …, 2010 - Wiley Online Library
Adipogenesis and osteogenesis, a reciprocal relationship in bone marrow, are complex
processes including proliferation of precursor cells, commitment to the specific lineage, and …
processes including proliferation of precursor cells, commitment to the specific lineage, and …
Neurotoxins: free radical mechanisms and melatonin protection
Toxins that pass through the blood-brain barrier put neurons and glia in peril. The damage
inflicted is usually a consequence of the ability of these toxic agents to induce free radical …
inflicted is usually a consequence of the ability of these toxic agents to induce free radical …
Melatonin regulates mesenchymal stem cell differentiation: a review
Among the numerous functions of melatonin, the control of survival and differentiation of
mesenchymal stem cells (MSCs) has been recently proposed. MSCs are a heterogeneous …
mesenchymal stem cells (MSCs) has been recently proposed. MSCs are a heterogeneous …
Melatonin administration to wild‐type mice and nontreated NLRP 3 mutant mice share similar inhibition of the inflammatory response during sepsis
The NLRP 3 inflammasome is involved in the innate immune response during inflammation.
Moreover, melatonin blunts the NF‐κB/NLRP 3 connection during sepsis. Thus, we …
Moreover, melatonin blunts the NF‐κB/NLRP 3 connection during sepsis. Thus, we …
Melatonin prevents bone destruction in mice with retinoic acid–induced osteoporosis
X Wang, T Liang, Y Zhu, J Qiu, X Qiu, C Lian, B Gao… - Molecular …, 2019 - Springer
Background The protective effect of melatonin against bone metabolism imbalance in
osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this …
osteoporosis (OP) induced by drugs such as retinoic acid (RA) is unclear. The aim of this …