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Alternative splicing and related RNA binding proteins in human health and disease
Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …
engendering transcript diversity, and modifications in protein structure and functionality …
The tau of MARK: a polarized view of the cytoskeleton
D Matenia, EM Mandelkow - Trends in biochemical sciences, 2009 - cell.com
Microtubule-affinity regulating kinases (MARKs) were originally discovered by their ability to
phosphorylate tau protein and related microtubule-associated proteins (MAPs), and thereby …
phosphorylate tau protein and related microtubule-associated proteins (MAPs), and thereby …
Genome-wide analysis of genetic loci associated with Alzheimer disease
Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …
The regulation and function of mammalian AMPK‐related kinases
NJ Bright, C Thornton, D Carling - Acta physiologica, 2009 - Wiley Online Library
AMP‐activated protein kinase (AMPK) is a key regulator of cellular and whole‐body energy
homeostasis. Recently, 12 AMPK‐related kinases (BRSK1, BRSK2, NUAK1, NUAK2, QIK …
homeostasis. Recently, 12 AMPK‐related kinases (BRSK1, BRSK2, NUAK1, NUAK2, QIK …
Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell …
Microtubule affinity-regulating kinase 4 (MARK4) is a potential drug target as the same is
found to be over expressed in several types of cancers. In search of effective MARK4 …
found to be over expressed in several types of cancers. In search of effective MARK4 …
Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy
The human genome encodes more than 500 protein kinases that work by transferring the γ-
phosphate group from ATP to serine, threonine, or tyrosine (Ser/Thr/Tyr) residues. Various …
phosphate group from ATP to serine, threonine, or tyrosine (Ser/Thr/Tyr) residues. Various …
Therapeutic targeting of microtubule affinity‐regulating kinase 4 in cancer and neurodegenerative diseases
Microtubule affinity‐regulating kinase 4 (MARK4) is a member of the Ser/Thr protein kinase
family, phosphorylates the microtubule‐connected proteins and plays a vital role in causing …
family, phosphorylates the microtubule‐connected proteins and plays a vital role in causing …
Microtubule affinity-regulating kinase 4: structure, function, and regulation
MAP/Microtubule affinity-regulating kinase 4 (MARK4) belongs to the family of
serine/threonine kinases that phosphorylate the microtubule-associated proteins (MAP) …
serine/threonine kinases that phosphorylate the microtubule-associated proteins (MAP) …
Structure and function of polarity‐inducing kinase family MARK/Par‐1 within the branch of AMPK/Snf1‐related kinases
A Marx, C Nugoor, S Panneerselvam… - The FASEB …, 2010 - Wiley Online Library
Kinases of the MARK/Par‐1 family of S/T protein kinases are regulators of diverse cellular
processes in Caenorhabditis elegans, Drosophila, yeast, and mammalian cells. They are …
processes in Caenorhabditis elegans, Drosophila, yeast, and mammalian cells. They are …
The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis
S Kuhns, KN Schmidt, J Reymann, DF Gilbert… - Journal of Cell …, 2013 - rupress.org
The primary cilium is a conserved microtubule (MT)-based structure that plays important
roles in coordinating key signaling pathways in both embryonic and adult tissues (D'Angelo …
roles in coordinating key signaling pathways in both embryonic and adult tissues (D'Angelo …