Alternative splicing and related RNA binding proteins in human health and disease

Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

The tau of MARK: a polarized view of the cytoskeleton

D Matenia, EM Mandelkow - Trends in biochemical sciences, 2009 - cell.com
Microtubule-affinity regulating kinases (MARKs) were originally discovered by their ability to
phosphorylate tau protein and related microtubule-associated proteins (MAPs), and thereby …

Genome-wide analysis of genetic loci associated with Alzheimer disease

S Seshadri, AL Fitzpatrick, MA Ikram, AL DeStefano… - Jama, 2010 - jamanetwork.com
Context Genome-wide association studies (GWAS) have recently identified CLU, PICALM,
and CR1 as novel genes for late-onset Alzheimer disease (AD). Objectives To identify and …

The regulation and function of mammalian AMPK‐related kinases

NJ Bright, C Thornton, D Carling - Acta physiologica, 2009 - Wiley Online Library
AMP‐activated protein kinase (AMPK) is a key regulator of cellular and whole‐body energy
homeostasis. Recently, 12 AMPK‐related kinases (BRSK1, BRSK2, NUAK1, NUAK2, QIK …

Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell …

B Aneja, NS Khan, P Khan, A Queen, A Hussain… - European Journal of …, 2019 - Elsevier
Microtubule affinity-regulating kinase 4 (MARK4) is a potential drug target as the same is
found to be over expressed in several types of cancers. In search of effective MARK4 …

Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy

S Anwar, M Shahwan, GM Hasan, A Islam, MI Hassan - Cellular Signalling, 2022 - Elsevier
The human genome encodes more than 500 protein kinases that work by transferring the γ-
phosphate group from ATP to serine, threonine, or tyrosine (Ser/Thr/Tyr) residues. Various …

Therapeutic targeting of microtubule affinity‐regulating kinase 4 in cancer and neurodegenerative diseases

M Alam, S Ahmed, M Abid, GM Hasan… - Journal of Cellular …, 2023 - Wiley Online Library
Microtubule affinity‐regulating kinase 4 (MARK4) is a member of the Ser/Thr protein kinase
family, phosphorylates the microtubule‐connected proteins and plays a vital role in causing …

Microtubule affinity-regulating kinase 4: structure, function, and regulation

F Naz, F Anjum, A Islam, F Ahmad… - Cell biochemistry and …, 2013 - Springer
MAP/Microtubule affinity-regulating kinase 4 (MARK4) belongs to the family of
serine/threonine kinases that phosphorylate the microtubule-associated proteins (MAP) …

Structure and function of polarity‐inducing kinase family MARK/Par‐1 within the branch of AMPK/Snf1‐related kinases

A Marx, C Nugoor, S Panneerselvam… - The FASEB …, 2010 - Wiley Online Library
Kinases of the MARK/Par‐1 family of S/T protein kinases are regulators of diverse cellular
processes in Caenorhabditis elegans, Drosophila, yeast, and mammalian cells. They are …

The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis

S Kuhns, KN Schmidt, J Reymann, DF Gilbert… - Journal of Cell …, 2013 - rupress.org
The primary cilium is a conserved microtubule (MT)-based structure that plays important
roles in coordinating key signaling pathways in both embryonic and adult tissues (D'Angelo …