NMDA-type glutamate receptors (NMDARs) constitute one of the main glutamate (Glu)
targets in the central nervous system and are involved in synaptic plasticity, which is the …

Abstract Glycine transporters (GlyTs) are Na+/Cl−-dependent neurotransmitter transporters,
responsible for l-glycine uptake into the central nervous system. GlyTs are members of the …

Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport
sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs …

Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …

The serotonin transporter (SERT) initiates the reuptake of extracellular serotonin in the
synapse to terminate neurotransmission. The cryogenic electron microscopy structures of …

The treatment of chronic pain is poorly managed by current analgesics, and there is a need
for new classes of drugs. We recently developed a series of bioactive lipids that inhibit the …

ATB 0,+(SLC6A14) is a member of the amino acid transporter branch of the SLC6 family
along with GlyT1 (SLC6A9) and GlyT2 (SLC6A5), two glycine-specific transporters coupled …

Abstract Glycine Transporter 2 (GlyT2) inhibitors have shown considerable potential as
analgesics for the treatment of neuropathic pain but also display considerable side effects …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

Transporters in the SLC6 family play key roles in regulating neurotransmission and are the
targets for a wide range of therapeutics. Important insights into the transport mechanisms …