Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from slee** and waking to neurotransmitter secretion and cellular metabolism …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral
circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal …

Introduction: Circadian rhythms regulate much of gastrointestinal physiology including cell
proliferation, motility, digestion, absorption, and electrolyte balance. Disruption of circadian …

Dosing time accounts for a large variability in efficacy and/or toxicity for many drugs.
Therefore, chronotherapy has been shown to effectively improve drug efficacy and to reduce …

Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …

Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment
with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour …

It has been well established that the circadian clock plays a crucial role in the regulation of
almost every physiological process. It also plays a critical role in pathophysiological states …

Circadian rhythmicity in renal function suggests rhythmic adaptations in renal metabolism.
To decipher the role of the circadian clock in renal metabolism, we studied diurnal changes …

Kidney function is regulated by the circadian clock. Not only do glomerular filtration rate and
urinary excretion oscillate during the day, but the expressions of several renal transporter …