Pathophysiological mechanisms involved in overactive Bladder/Detrusor overactivity
R Chess-Williams, DJ Sellers - Current Bladder Dysfunction Reports, 2023 - Springer
Abstract Purpose of Review To examine the latest published findings on the
pathophysiological mechanisms involved in the development of overactive bladder (OAB) …
pathophysiological mechanisms involved in the development of overactive bladder (OAB) …
Gene therapy for overactive bladder: a review of BK-channel α-subunit gene transfer
A need exists for local (ie, bladder-specific) interventions to treat overactive bladder (OAB)
with low risk of unwanted postprocedural outcomes. Gene therapy targeted to leverage …
with low risk of unwanted postprocedural outcomes. Gene therapy targeted to leverage …
The five primary prostaglandins stimulate contractions and phasic activity of the urinary bladder urothelium, lamina propria and detrusor
Background Inflammation is often associated with several bladder dysfunctions, including
overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS). As such …
overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/PBS). As such …
Afferent nerve activity in a mouse model increases with faster bladder filling rates in vitro, but voiding behavior remains unaltered in vivo
Storage and voiding functions in urinary bladder are well-known, yet fundamental
physiological events coordinating these behaviors remain elusive. We sought to understand …
physiological events coordinating these behaviors remain elusive. We sought to understand …
Increased Afferent Nerve Firing Is Correlated With the Detection of Bladder Wall Micromotion in a Perfused Ex‐Vivo Porcine Model
RW Fogg, MP Ghatas, B McCormack… - Neurourology and …, 2025 - Wiley Online Library
ABSTRACT Introduction and Objective Observable autonomous rhythmic changes in
intravesical pressure, termed bladder wall micromotion, is a phenomenon that has been …
intravesical pressure, termed bladder wall micromotion, is a phenomenon that has been …
X-ray videocystometry for high-speed monitoring of urinary tract function in mice
J Franken, H De Bruyn, R Rietjens, A Segal… - Science …, 2021 - science.org
Lower urinary tract dysfunction (LUTd) represents a major health care problem with a high,
unmet medical need. Design of additional therapies for LUTd requires precise tools to study …
unmet medical need. Design of additional therapies for LUTd requires precise tools to study …
[HTML][HTML] Bladder wall micromotion measured by non-invasive ultrasound: initial results in women with and without overactive bladder
Objective: Rhythmic contractions of the bladder wall during filling result from the
synchronization of bladder wall micromotion and are often observed in the urodynamic …
synchronization of bladder wall micromotion and are often observed in the urodynamic …
Which of the primary prostaglandin receptors might play a role in lower urinary tract dysfunction?: A narrative review
This article reviews the role of inflammation in bladder dysfunction, and the potential for
prostaglandins to play a contributing role. If this is the case, it presents this receptor system …
prostaglandins to play a contributing role. If this is the case, it presents this receptor system …
Can cardiac pressure-volume catheters improve urodynamic assessment? an ex-vivo proof-of-concept
Aims To explore the feasibility of using pressure-volume (PV) catheters for cystometry.
These catheters are well-established in cardiovascular research for simultaneous pressure …
These catheters are well-established in cardiovascular research for simultaneous pressure …
A prospective paired comparison trial of mirabegron and anticholinergics in patients with low bladder compliance
HS Son, JH Kim - 2024 - researchsquare.com
Purpose Low bladder compliance (BC) remains a major challenge. Nevertheless, studies on
the drug mechanisms that improve BC are rare. We investigated the efficacy of a β3 …
the drug mechanisms that improve BC are rare. We investigated the efficacy of a β3 …