Targeting innate immune mediators in type 1 and type 2 diabetes
MY Donath, CA Dinarello… - Nature Reviews …, 2019 - nature.com
Type 1 and type 2 diabetes are characterized by chronic inflammation; both diseases
involve pancreatic islet inflammation, while systemic low-grade inflammation is a feature of …
involve pancreatic islet inflammation, while systemic low-grade inflammation is a feature of …
Signaling pathways in inflammation and anti-inflammatory therapies
YT Yeung, F Aziz, A Guerrero-Castilla… - Current …, 2018 - ingentaconnect.com
During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …
Insulin resistance and diabetes mellitus in Alzheimer's disease
Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …
insulin resistance. The term insulin resistance is very wide and could affect different proteins …
Targeting inflammation in the treatment of type 2 diabetes: time to start
MY Donath - Nature reviews Drug discovery, 2014 - nature.com
The role of inflammation in the pathogenesis of type 2 diabetes and associated
complications is now well established. Several conditions that are driven by inflammatory …
complications is now well established. Several conditions that are driven by inflammatory …
[HTML][HTML] Type 2 diabetes mellitus: from a metabolic disorder to an inflammatory condition
I Hameed, SR Masoodi, SA Mir, M Nabi… - World journal of …, 2015 - ncbi.nlm.nih.gov
Diabetes mellitus is increasing at an alarming rate and has become a global challenge.
Insulin resistance in target tissues and a relative deficiency of insulin secretion from …
Insulin resistance in target tissues and a relative deficiency of insulin secretion from …
Islet inflammation in type 2 diabetes and physiology
K Eguchi, R Nagai - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …
dysfunction has further highlighted the significance of inflammation in metabolic diseases …
Type 2 diabetes as a protein misfolding disease
A Mukherjee, D Morales-Scheihing, PC Butler… - Trends in molecular …, 2015 - cell.com
Type 2 diabetes (T2D) is a highly prevalent and chronic metabolic disorder. Recent
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …
evidence suggests that formation of toxic aggregates of the islet amyloid polypeptide (IAPP) …
Islet inflammation in type 2 diabetes
M Böni-Schnetzler, DT Meier - Seminars in immunopathology, 2019 - Springer
Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …
failure is a major component of the pathogenesis of type 2 diabetes. It is now well …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity
MY Donath, É Dalmas, NS Sauter, M Böni-Schnetzler - Cell metabolism, 2013 - cell.com
The role of the immune system is to restore functionality in response to stress. Increasing
evidence shows that this function is not limited to insults by infection or injury and plays a …
evidence shows that this function is not limited to insults by infection or injury and plays a …