A new aspect of cell membrane structure is presented, based on the dynamic clustering of
sphingolipids and cholesterol to form rafts that move within the fluid bilayer. It is proposed …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

Primary cilium dysfunction underlies the pathogenesis of Bardet-Biedl syndrome (BBS), a
genetic disorder whose symptoms include obesity, retinal degeneration, and nephropathy …

Rab GTPases control intracellular membrane traffic by recruiting specific effector proteins to
restricted membranes in a GTP-dependent manner. In this Cell Science at a Glance and the …

Spermatogenesis is the process by which a single spermatogonium develops into 256
spermatozoa, one of which will fertilize the ovum. Since the 1950s when the stages of the …

Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate
the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral …

Vesicular/membrane trafficking essentially regulates the compartmentalization and
abundance of proteins within the cells and contributes in many signalling pathways. This …

Probiotic bacteria are microorganisms that benefit the host by preventing or ameliorating
disease. However, little information is known regarding the scientific rationale for using …

Using a new mAb raised against the mouse neuroepithelium, we have identified and cDNA-
cloned prominin, an 858-amino acid-containing, 115-kDa glycoprotein. Prominin is a novel …

Rab7 is a small GTPase that controls transport to endocytic degradative compartments. Here
we report the identification of a novel 45 kDa protein that specifically binds Rab7GTP at its C …