Food protein-derived bioactive peptides are recognized as valuable ingredients of functional
foods and/or nutraceuticals to promote health and reduce the risk of chronic diseases …

Oral delivery of peptide and protein drugs faces immense challenge partially due to the
gastrointestinal (GI) environment. In spite of considerable efforts by industrial and academic …

New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are
being developed every year, making it vital to find a non-invasive route such as nasal or …

The central nervous system is well protected by the blood–brain barrier (BBB) which
maintains its homeostasis. Due to this barrier many potential drugs for the treatment of …

N‐Methylation is one of the simplest chemical modifications often occurring in peptides and
proteins of prokaryotes and higher eukaryotes. Over years of evolution, nature has …

The influence of physicochemical properties, including lipophilicity, H-bonding capacity and
molecular size and shape descriptors on brain uptake has been investigated using a …

The renaissance of peptides in pharmaceutical industry results from their importance in
many biological functions. However, low metabolic stability and the lack of oral availability of …

In this review, we first summarize the structure and properties of biological membranes and
the routes of passive drug transfer through physiological barriers. Lipophilicity is then …

Elastin is an important protein of the extracellular matrix of higher vertebrates, which confers
elasticity and resilience to various tissues and organs including lungs, skin, large blood …

For decades, the development of peptides as potential drugs was aimed solely at peptides
with the highest affinity, receptor selectivity, or stability against enzymatic degradation …