The purpose of this review is to summarize the research progress of PI3K/Akt signaling
pathway in erythropoiesis and glycolysis. Phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …

Abstract Hypoxia‐inducible factor 1 (HIF‐1) is a transcriptional activator that mediates
adaptive responses to hypoxia. HIF‐1 activity is increased in the majority of human cancers …

Sleep‐disordered breathing with recurrent apnea (periodic cessation of breathing) results in
chronic intermittent hypoxia (IH), which leads to cardiovascular and respiratory pathology …

Factor inhibiting HIF-1α (FIH) is an asparaginyl hydroxylase. Hydroxylation of HIF-α proteins
by FIH blocks association of HIFs with the transcriptional coactivators CBP/p300, thus …

Using a cell-based reporter gene assay, we screened a library of drugs in clinical use and
identified the anthracycline chemotherapeutic agents doxorubicin and daunorubicin as …

Sleep-disordered breathing with recurrent apnea is a major cause of morbidity and mortality.
Affected individuals have increased risk of systemic hypertension. Sleep apnea results in …

Hypoxia is defined as a reduction in oxygen supply to a tissue below physiological levels.
However, physiological hypoxic conditions occur during early embryonic development; and …

Factor inhibiting HIF (FIH, also known as HIF1AN) is an oxygen-dependent asparaginyl
hydroxylase that regulates the hypoxia-inducible factors (HIFs). Several proteins containing …

The hypoxia inducible transcription factors (HIFs) are regulated at the level of protein
stability and transcriptional activity in an oxygen‐dependent manner by prolyl and …

Aberrant activation of the hypoxia inducible factor (HIF) pathway causing overexpression of
angiogenic genes, like vascular endothelial growth factor (VEGF), is one of the underlying …