The APOBEC protein family: united by structure, divergent in function
JD Salter, RP Bennett, HC Smith - Trends in biochemical sciences, 2016 - cell.com
The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …
have diverse and important functions in human health and disease. These proteins have an …
Key viral adaptations preceding the AIDS pandemic
D Sauter, F Kirchhoff - Cell host & microbe, 2019 - cell.com
HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-
species transmissions and recombination events as well as changes in the repertoire and …
species transmissions and recombination events as well as changes in the repertoire and …
[HTML][HTML] The structural basis for HIV-1 Vif antagonism of human APOBEC3G
YL Li, CA Langley, CM Azumaya, I Echeverria… - Nature, 2023 - nature.com
Abstract The APOBEC3 (A3) proteins are host antiviral cellular proteins that hypermutate the
viral genome of diverse viral families. In retroviruses, this process requires A3 packaging …
viral genome of diverse viral families. In retroviruses, this process requires A3 packaging …
Origin of the HIV-1 group O epidemic in western lowland gorillas
HIV-1, the cause of AIDS, is composed of four phylogenetic lineages, groups M, N, O, and P,
each of which resulted from an independent cross-species transmission event of simian …
each of which resulted from an independent cross-species transmission event of simian …
Suppression of APOBEC3-mediated restriction of HIV-1 by Vif
The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
suppress replication of viruses with a single-stranded DNA intermediate by inducing …
Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants
EJD Greenwood, NJ Matheson, K Wals… - Elife, 2016 - elifesciences.org
Viruses manipulate host factors to enhance their replication and evade cellular restriction.
We used multiplex tandem mass tag (TMT)-based whole cell proteomics to perform a …
We used multiplex tandem mass tag (TMT)-based whole cell proteomics to perform a …
Identification of the HIV-1 Vif and human APOBEC3G protein interface
M Letko, T Booiman, N Kootstra, V Simon, M Ooms - Cell reports, 2015 - cell.com
Human cells express natural antiviral proteins, such as APOBEC3G (A3G), that potently
restrict HIV replication. As a counter-defense, HIV encodes the accessory protein Vif, which …
restrict HIV replication. As a counter-defense, HIV encodes the accessory protein Vif, which …
Structure-guided analysis of the human APOBEC3-HIV restrictome
H Aydin, MW Taylor, JE Lee - Structure, 2014 - cell.com
Human APOBEC3 (A3) proteins are host-encoded intrinsic restriction factors that inhibit the
replication of many retroviral pathogens. Restriction is believed to occur as a result of the …
replication of many retroviral pathogens. Restriction is believed to occur as a result of the …
Examination of the APOBEC3 barrier to cross species transmission of primate lentiviruses
The transmission of viruses from animal hosts into humans have led to the emergence of
several diseases. Usually these cross-species transmissions are blocked by host restriction …
several diseases. Usually these cross-species transmissions are blocked by host restriction …
Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization
Abstract The seven APOBEC3 (A3) enzymes in primates restrict HIV/SIV replication to
differing degrees by deaminating cytosine in viral (−) DNA, which forms promutagenic …
differing degrees by deaminating cytosine in viral (−) DNA, which forms promutagenic …