Inadequate or excessive nutrient consumption leads to oxidative stress, which may disrupt
oxidative homeostasis, activate a cascade of molecular pathways, and alter the metabolic …

Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

Obesity has reached epidemic proportions and pregnancies in obese mothers have
increased risk for complications including gestational diabetes, hypertensive disorders …

Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …

Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Accumulating evidence suggests that insults occurring during the perinatal period alter the
developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes …

Maternal obesity is thought to increase the offspring's risk of juvenile obesity and metabolic
diseases; however, the mechanism (s) whereby excess maternal nutrition affects fetal …

Sex differences occur in most non-communicable diseases, including metabolic diseases,
hypertension, cardiovascular disease, psychiatric and neurological disorders and cancer. In …

Transgenerational epigenetic effects include all processes that have evolved to achieve the
nongenetic determination of phenotype. There has been a long-standing interest in this area …