Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

CNS immune defenses are marshaled and dominated by brain resident macrophages and
microglia, which are the innate immune sentinels and frontline host immune barriers against …

Heterotypic interactions across diverse cell types can enable tumor progression and hold
the potential to expand therapeutic interventions. Here, combined profiling and functional …

Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing
glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified …

Glioblastoma (GBM) is one of the most aggressive tumors in the adult central nervous
system. We previously revealed that circadian regulation of glioma stem cells (GSCs) affects …

Purpose: The blood–brain barrier (BBB) inhibits adequate dosing/penetration of therapeutic
agents to malignancies in the brain. Low-intensity pulsed ultrasound (LIPU) is a safe …

The glioblastoma (GBM) stem cell–like cells (GSCs) are critical for tumorigenesis/therapeutic
resistance of GBM. Mounting evidence supports tumor-promoting function of long noncoding …

Glioblastoma ranks among the most lethal of all human cancers. Glioblastomas display
striking cellular heterogeneity, with stem-like glioblastoma stem cells (GSCs) at the apex …

Glioblastoma (GBM), the most common and lethal primary brain tumor, with a median
survival rate of only 15 months, remains incurable despite intensive multimodal treatment of …

Extracellular acidification is a well-known driver of tumorigenesis that has been extensively
studied. In contrast, the role of endosomal pH is novel and relatively unexplored. There is …