Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant containing various
flavonolignans (with silybin being the major one), has received a tremendous amount of …

Inflammation is a biological defense mechanism caused by the interruption of the tissue
homeostasis caused by the presence of a biological, chemical, or physical agents in the …

The correct concentration of oxygen in all tissues is a hallmark of cellular wellness, and the
negative regulation of oxygen homeostasis is able to affect the cells and tissues of the whole …

The inflammation is the protective response of the body against various harmful stimuli;
however, the aberrant and inappropriate activation tends to become harmful. The acute …

Hepatocellular carcinoma (HCC) has become a leading cause of cancer-related death,
making the elucidation of its underlying mechanisms an urgent priority. Inflammation is an …

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …

Background Bipolar disorder phenomenologically is a biphasic disorder of energy
availability; increased in mania and decreased in depression. In consort, there is …

The onco-suppressor p53 is a transcription factor that regulates a wide spectrum of genes
involved in various cellular functions including apoptosis, cell cycle arrest, senescence …

Redox biology is a very quickly develo** area of modern biological sciences, and roles of
redox homeostasis in health and disease have recently received tremendous attention …

Recent advances in pharmacogenomics have generated a wealth of data of different types
whose analysis have helped in the identification of signatures of different cellular …