Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …

Singlet oxygen: Properties, generation, detection, and environmental applications

Y Wang, Y Lin, S He, S Wu, C Yang - Journal of hazardous materials, 2024 - Elsevier
Abstract Singlet oxygen (1 O 2) is molecular oxygen in the excited state with high energy
and electrophilic properties. It is widely found in nature, and its important role is gradually …

Conquering the hypoxia limitation for photodynamic therapy

Y Wan, LH Fu, C Li, J Lin, P Huang - Advanced Materials, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Y **ong, C **ao, Z Li, X Yang - Chemical Society Reviews, 2021 - pubs.rsc.org
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …

Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy

LS Lin, J Song, L Song, K Ke, Y Liu, Z Zhou… - Angewandte …, 2018 - Wiley Online Library
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells
by converting endogenous H2O2 into the highly toxic hydroxyl radical (. OH). There is a …

Pt Decorated Ti3C2Tx MXene with NIR-II Light Amplified Nanozyme Catalytic Activity for Efficient Phototheranostics

Y Zhu, Z Wang, R Zhao, Y Zhou, L Feng, S Gai… - ACS nano, 2022 - ACS Publications
The clinical application of photothermal therapy (PTT) is severely limited by the tissue
penetration depth of excitation light, and enzyme therapy is hampered by its low therapeutic …

Metal-based photosensitizers as inducers of regulated cell death mechanisms

Y Zhang, BT Doan, G Gasser - Chemical Reviews, 2023 - ACS Publications
Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …

Photosensitizers for photodynamic therapy

M Lan, S Zhao, W Liu, CS Lee… - Advanced healthcare …, 2019 - Wiley Online Library
As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes
advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by …

Tumor‐microenvironment‐activated reactive oxygen species amplifier for enzymatic cascade cancer starvation/chemodynamic/immunotherapy

M Wang, M Chang, C Li, Q Chen, Z Hou… - Advanced …, 2022 - Wiley Online Library
At present, some progress has been made in the field of cancer theranostics based on
nanocatalysts (NCs), but achieving precise theranostics in response to the specific tumor …

Type I photosensitizers revitalizing photodynamic oncotherapy

D Chen, Q Xu, W Wang, J Shao, W Huang, X Dong - Small, 2021 - Wiley Online Library
Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of
non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II …