Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy
B Niu, K Liao, Y Zhou, T Wen, G Quan, X Pan, C Wu - Biomaterials, 2021 - Elsevier
Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …
high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) …
Singlet oxygen: Properties, generation, detection, and environmental applications
Y Wang, Y Lin, S He, S Wu, C Yang - Journal of hazardous materials, 2024 - Elsevier
Abstract Singlet oxygen (1 O 2) is molecular oxygen in the excited state with high energy
and electrophilic properties. It is widely found in nature, and its important role is gradually …
and electrophilic properties. It is widely found in nature, and its important role is gradually …
Conquering the hypoxia limitation for photodynamic therapy
Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …
Engineering nanomedicine for glutathione depletion-augmented cancer therapy
Y **ong, C **ao, Z Li, X Yang - Chemical Society Reviews, 2021 - pubs.rsc.org
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …
Simultaneous Fenton‐like Ion Delivery and Glutathione Depletion by MnO2‐Based Nanoagent to Enhance Chemodynamic Therapy
Chemodynamic therapy (CDT) utilizes iron‐initiated Fenton chemistry to destroy tumor cells
by converting endogenous H2O2 into the highly toxic hydroxyl radical (. OH). There is a …
by converting endogenous H2O2 into the highly toxic hydroxyl radical (. OH). There is a …
Pt Decorated Ti3C2Tx MXene with NIR-II Light Amplified Nanozyme Catalytic Activity for Efficient Phototheranostics
Y Zhu, Z Wang, R Zhao, Y Zhou, L Feng, S Gai… - ACS nano, 2022 - ACS Publications
The clinical application of photothermal therapy (PTT) is severely limited by the tissue
penetration depth of excitation light, and enzyme therapy is hampered by its low therapeutic …
penetration depth of excitation light, and enzyme therapy is hampered by its low therapeutic …
Metal-based photosensitizers as inducers of regulated cell death mechanisms
Y Zhang, BT Doan, G Gasser - Chemical Reviews, 2023 - ACS Publications
Over the last few decades, various forms of regulated cell death (RCD) have been
discovered and were found to improve cancer treatment. Although there are several reviews …
discovered and were found to improve cancer treatment. Although there are several reviews …
Photosensitizers for photodynamic therapy
M Lan, S Zhao, W Liu, CS Lee… - Advanced healthcare …, 2019 - Wiley Online Library
As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes
advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by …
advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by …
Tumor‐microenvironment‐activated reactive oxygen species amplifier for enzymatic cascade cancer starvation/chemodynamic/immunotherapy
M Wang, M Chang, C Li, Q Chen, Z Hou… - Advanced …, 2022 - Wiley Online Library
At present, some progress has been made in the field of cancer theranostics based on
nanocatalysts (NCs), but achieving precise theranostics in response to the specific tumor …
nanocatalysts (NCs), but achieving precise theranostics in response to the specific tumor …
Type I photosensitizers revitalizing photodynamic oncotherapy
Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of
non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II …
non‐invasiveness, high selectivity, and minimal side effects. However, conventional type II …