Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …

Immunoglobulin E (IgE)‐mediated allergy is the most common hypersensitivity disease
affecting more than 30% of the population. Exposure to even minute quantities of allergens …

Anaphylaxis is a severe systemic hypersensitivity reaction that is rapid in onset;
characterized by life-threatening airway, breathing, and/or circulatory problems; and usually …

▪ Abstract This review focuses on recent progress in our understanding of how mast cells
can contribute to the initiation, development, expression, and regulation of acquired immune …

Calcium (Ca2+) is an essential signaling molecule that controls a wide range of biological
functions. In the immune system, calcium signals play a central role in a variety of cellular …

Urticaria (hives) is a highly prevalent skin disorder that can occur with or without associated
angioedema. Chronic spontaneous urticaria (CSU) is a condition which persists for more …

Mast cells (MCs) influence intercellular communication during inflammation by secreting
cytoplasmic granules that contain diverse mediators. Here, we have demonstrated that MCs …

The high-affinity Fc receptor for IgE (FcεRI), a multimeric immune receptor, is a crucial
structure for IgE-mediated allergic reactions. In recent years, advances have been made in …

Mast cells are unique tissue-resident immune cells of the myeloid lineage that have long
been implicated in the pathogenesis of allergic and autoimmune disorders. More recently …