The main focus of this review is the role of mammary stem cells in normal breast
development and carcinogenesis. We have developed a new in vitro culture system that …

New neurons are generated throughout adulthood in two regions of the brain, the olfactory
bulb and dentate gyrus of the hippocampus, and are incorporated into the hippocampal …

Transformed stem cells have been isolated from some human cancers. We report that,
unlike other brain cancers, the lethal glioblastoma multiforme contains neural precursors …

Neural stem cells (NSCs) yield both neuronal and glial progeny, but their differentiation
potential toward multiple region-specific neuron types remains remarkably poor. In contrast …

Human pluripotent stem cells (hPSCs) have been differentiated efficiently to neuronal cell
types. However, directed differentiation of hPSCs to astrocytes and astroglial subtypes …

Here we present a protocol for extraction and culture of neurons from adult rat or mouse
CNS. The method proscribes an optimized protease digestion of slices, control of osmolarity …

Neurogenesis occurs in the adult mammalian brain and may play roles in learning and
memory processes and recovery from injury, suggesting that abnormalities in neural …

Graft survival and integration are major factors that limit the efficacy of cell therapies for the
treatment of disease and injury in the central nervous system. Efforts to improve cell survival …

Nitric oxide (NO) is believed to act as an intercellular signal that regulates synaptic plasticity
in mature neurons. We now report that NO also regulates the proliferation and differentiation …

Regionally and functionally diverse types of astrocytes exist throughout the central nervous
system and participate in nearly every aspect of normal and abnormal neural function …