Metastatic colorectal cancer (mCRC) remains a lethal disease with an approximately 14% 5-
year survival rate. While early-stage colorectal cancer (CRC) can be cured by surgery with …

MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the
expression of target genes post-transcriptionally and interact with mRNA-coding genes …

Gene therapy, as a revolutionary treatment, has been gaining more and more attention. The
key to gene therapy is the selection of suitable vectors for protection of exogenous nucleic …

Mesenchymal stem cells (MSCs) are becoming hotspots for application in disease therapies
recently, combining with biomaterials and drug delivery system. A major advantage of MSCs …

Epigenetic regulation by microRNAs (miRs) demonstrated a promising therapeutic potential
of these molecules to regulate genetic activity in different cancers, including colorectal …

Tumour metastasis is one of the major factors leading to poor prognosis as well as lower
survival among cancer patients. A number of studies investigating the inhibition of tumour …

Growth and metastasis of colorectal cancer is closely connected to the biosynthetic capacity
of tumor cells, and colorectal cancer stem cells that reside at the top of the intratumoral …

MicroRNAs (miRNAs) are small non‑coding RNAs that serve key roles in cell proliferation,
migration, invasion and apoptosis by regulating gene expression. In malignant tumors …

Colorectal cancer (CRC) is a prevalent malignant tumor in the gastrointestinal tract, with
around 50% of patients experiencing distant metastases, predominantly to the liver …

MiRNAs (microRNAs) constitute a group of diminutive molecules of non-coding RNA
intricately involved in regulating gene expression. This regulation is primarily accomplished …