[HTML][HTML] High-content CRISPR screening

C Bock, P Datlinger, F Chardon, MA Coelho… - Nature Reviews …, 2022‏ - nature.com
CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

Artificial intelligence and machine learning disciplines with the potential to improve the nanotoxicology and nanomedicine fields: a comprehensive review

AV Singh, M Varma, P Laux, S Choudhary… - Archives of …, 2023‏ - Springer
The use of nanomaterials in medicine depends largely on nanotoxicological evaluation in
order to ensure safe application on living organisms. Artificial intelligence (AI) and machine …

Artificial intelligence for cardiovascular disease risk assessment in personalised framework: a sco** review

M Singh, A Kumar, NN Khanna, JR Laird… - …, 2024‏ - thelancet.com
Background The field of precision medicine endeavors to transform the healthcare industry
by advancing individualised strategies for diagnosis, treatment modalities, and predictive …

AiZynth impact on medicinal chemistry practice at AstraZeneca

JD Shields, R Howells, G Lamont, Y Leilei… - RSC Medicinal …, 2024‏ - pubs.rsc.org
AstraZeneca chemists have been using the AI retrosynthesis tool AiZynth for three years. In
this article, we present seven examples of how medicinal chemists using AiZynth positively …

Success stories of AI in drug discovery-where do things stand?

KK Mak, MK Balijepalli, MR Pichika - Expert opinion on drug …, 2022‏ - Taylor & Francis
Introduction Artificial intelligence (AI) in drug discovery and development (DDD) has gained
more traction in the past few years. Many scientific reviews have already been made …

Artificial intelligence and machine learning for lead-to-candidate decision-making and beyond

D McNair - Annual review of pharmacology and toxicology, 2023‏ - annualreviews.org
The use of artificial intelligence (AI) and machine learning (ML) in pharmaceutical research
and development has to date focused on research: target identification; docking-, fragment …

A roadmap to creating ferroptosis-based medicines

K Hadian, BR Stockwell - Nature chemical biology, 2021‏ - nature.com
Ferroptosis is a regulated form of non-apoptotic cell death implicated in pathological
settings. To be exploited clinically, ferroptosis requires reagents that unequivocally detect …

High throughput microscopy and single cell phenotypic image-based analysis in toxicology and drug discovery

F Stossi, PK Singh, K Safari, M Marini, D Labate… - Biochemical …, 2023‏ - Elsevier
Measuring single cell responses to the universe of chemicals (drugs, natural products,
environmental toxicants etc.) is of paramount importance to human health as phenotypic …

Patient‐derived microphysiological systems for precision medicine

J Ko, J Song, N Choi, HN Kim - Advanced Healthcare Materials, 2024‏ - Wiley Online Library
Patient‐derived microphysiological systems (P‐MPS) have emerged as powerful tools in
precision medicine that provide valuable insight into individual patient characteristics. This …

Predicting cell morphological responses to perturbations using generative modeling

A Palma, FJ Theis, M Lotfollahi - Nature Communications, 2025‏ - nature.com
Advancements in high-throughput screenings enable the exploration of rich phenotypic
readouts through high-content microscopy, expediting the development of phenotype-based …