Obesity is a chronic disease associated with increased risk of obesity-related complications
and mortality. Our better understanding of the weight regulation mechanisms and the role of …

Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Cachexia, a systemic wasting condition, is considered a late consequence of diseases,
including cancer, organ failure, or infections, and contributes to significant morbidity and …

Abstract Growth differentiation factor 15 (GDF15) is a member of the TGFβ superfamily
whose expression is increased in response to cellular stress and disease as well as by …

Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a
6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to …

Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type
2 diabetes in people at high risk,. More than 60% of this effect is attributable to the ability of …

Summary The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty
liver disease, but the underlying pathophysiology remains unclear. We studied the effect of …

Growth/differentiation factor-15 (GDF-15), also named macrophage inhibitory cytokine-1, is a
divergent member of the transforming growth factor β superfamily. While physiological …