[HTML][HTML] Pharmacokinetic aspects of retinal drug delivery

EM Del Amo, AK Rimpelä, E Heikkinen, OK Kari… - Progress in retinal and …, 2017 - Elsevier
Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

The role of anti-vascular endothelial growth factor (anti-VEGF) in the management of proliferative diabetic retinopathy

Y Zhao, RP Singh - Drugs in context, 2018 - pmc.ncbi.nlm.nih.gov
Diabetes is a major cause of visual impairment among working-age adults in the United
States. The proliferative form of diabetic retinopathy is associated with severe vision loss …

Ocular novel drug delivery: impacts of membranes and barriers

J Barar, AR Javadzadeh, Y Omidi - Expert opinion on drug delivery, 2008 - Taylor & Francis
Background: Ocular drug delivery is an extremely challenging area due to its restrictive
barrier functionalities. Objective: Drug transport via corneal/non-corneal routes involves …

Liposomes for intravitreal drug delivery: a state of the art

A Bochot, E Fattal - Journal of Controlled Release, 2012 - Elsevier
Intravitreal administration of drugs has raised a large interest during the last two decades
improving the treatment of infectious diseases of the posterior segment of the eye or …

Intraocular nano-microscale drug delivery systems for glaucoma treatment: design strategies and recent progress

Y Shen, J Sun, X Sun - Journal of Nanobiotechnology, 2023 - Springer
Glaucoma is a leading cause of irreversible visual impairment and blindness, affecting over
76.0 million people worldwide in 2020, with a predicted increase to 111.8 million by 2040 …

Nanoparticles toxicity and their routes of exposures

A Aydın, H Sipahi, M Charehsaz - Recent advances in novel drug …, 2012 - books.google.com
Nanotechnology is a new area that presents small sized materials, structures, devices, and
systems in last few decades. We hear about many materials and systems that contain …

Safety evaluation of ocular drug delivery formulations: techniques and practical considerations

BG Short - Toxicologic pathology, 2008 - journals.sagepub.com
Development of new drug candidates and novel delivery techniques for treatment of ocular
diseases has recently accelerated. Treatment of anterior-segment diseases has witnessed …

Encapsulation of dexamethasone into biodegradable polymeric nanoparticles

C Gómez-Gaete, N Tsapis, M Besnard, A Bochot… - International journal of …, 2007 - Elsevier
The present paper concerns both the optimization of dexamethasone (DXM) entrapment and
its release from biodegradable poly (d, l-lactide-co-glycolide)(PLGA) nanoparticles prepared …

Drug delivery to the retina: challenges and opportunities

S Duvvuri, S Majumdar, AK Mitra - Expert opinion on biological …, 2003 - Taylor & Francis
Retinal drug delivery is a challenging area in the field of ophthalmic drug delivery. An ideal
drug delivery system for the retina and vitreous humor has not yet been found, despite …

Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration

R Iezzi, BR Guru, IV Glybina, MK Mishra, A Kennedy… - Biomaterials, 2012 - Elsevier
Retinal neuroinflammation, mediated by activated microglia, plays a key role in the
pathogenesis of photoreceptor and retinal pigment epithelial cell loss in age-related macular …